ID E5DSI6_9CAUD Unreviewed; 155 AA.
AC E5DSI6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=frd {ECO:0000313|EMBL:ADQ53360.1};
GN ORFNames=65p352 {ECO:0000313|EMBL:ADQ53360.1};
OS Aeromonas phage 65.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Straboviridae; Emmerichvirinae; Ishigurovirus; Ishigurovirus osborne.
OX NCBI_TaxID=2919549 {ECO:0000313|EMBL:ADQ53360.1, ECO:0000313|Proteomes:UP000008727};
RN [1] {ECO:0000313|EMBL:ADQ53360.1, ECO:0000313|Proteomes:UP000008727}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21029436;
RA Petrov V.M., Ratnayaka S., Nolan J.M., Miller E.S., Karam J.D.;
RT "Genomes of the T4-related bacteriophages as windows on microbial genome
RT evolution.";
RL Virol. J. 7:292-292(2010).
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DR EMBL; GU459069; ADQ53360.1; -; Genomic_DNA.
DR RefSeq; YP_004301189.1; NC_015251.1.
DR GeneID; 10323629; -.
DR KEGG; vg:10323629; -.
DR OrthoDB; 9577at10239; -.
DR Proteomes; UP000008727; Segment.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008727}.
FT DOMAIN 1..154
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 155 AA; 17644 MW; 4EFD4BED19412F10 CRC64;
MPWPHIKEDM NKFRDVTINK TVVMGRGTFE SLPKRLHNRF HIVVSSSPDV VNENLEAPDL
IFDDLELLEK MMDESPHADF CIIGGPSLLY HFIDRADEVH MTVVKCGSMP PAEHCDVLLD
SQFTKRIPSE FDMIDCAALT TREGLNVVYT HFVKG
//
