ID E5RHB1_HUMAN Unreviewed; 162 AA.
AC E5RHB1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=EF-hand calcium binding domain 3 {ECO:0000313|Ensembl:ENSP00000428626.1};
DE Flags: Fragment;
GN Name=EFCAB3 {ECO:0000313|Ensembl:ENSP00000428626.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428626.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000428626.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000428626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC008026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RHB1; -.
DR SMR; E5RHB1; -.
DR MassIVE; E5RHB1; -.
DR PeptideAtlas; E5RHB1; -.
DR ProteomicsDB; 15925; -.
DR Antibodypedia; 18612; 52 antibodies from 19 providers.
DR Ensembl; ENST00000518576.1; ENSP00000428626.1; ENSG00000172421.10.
DR UCSC; uc060iku.1; human.
DR HGNC; HGNC:26379; EFCAB3.
DR VEuPathDB; HostDB:ENSG00000172421; -.
DR GeneTree; ENSGT00940000161358; -.
DR OMA; QMQAFQD; -.
DR ChiTaRS; EFCAB3; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000172421; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 59 other cell types or tissues.
DR ExpressionAtlas; E5RHB1; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR22656:SF1; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13; 1.
DR PANTHER; PTHR22656; UNCHARACTERIZED; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E5RHB1,
KW ECO:0007829|ProteomicsDB:E5RHB1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 83..118
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT NON_TER 162
FT /evidence="ECO:0000313|Ensembl:ENSP00000428626.1"
SQ SEQUENCE 162 AA; 18252 MW; C15D8DE58571CFAA CRC64;
MAVSEIKPKL KLNPLTKVPI SHNKRDRDLP GSLQCQLQHK EKKLSASQMA AFQDAYNFFY
KDKTGCIDFH GLMCTVAKLG MNLTKHDVYN ELKCADIDRD GKVNFSDFIK VLTDKNLFLK
AVVPEKETCL DLAGNPGILL FEILSRLLET SALPRKSIIE IV
//
