ID E5RJ69_HUMAN Unreviewed; 158 AA.
AC E5RJ69;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Src like adaptor {ECO:0000313|Ensembl:ENSP00000430596.1};
DE Flags: Fragment;
GN Name=SLA {ECO:0000313|Ensembl:ENSP00000430596.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430596.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000430596.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000430596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AF235100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF305872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RJ69; -.
DR SMR; E5RJ69; -.
DR MassIVE; E5RJ69; -.
DR PeptideAtlas; E5RJ69; -.
DR ProteomicsDB; 16508; -.
DR Antibodypedia; 1995; 152 antibodies from 28 providers.
DR Ensembl; ENST00000522119.5; ENSP00000430596.1; ENSG00000155926.14.
DR UCSC; uc064qjw.1; human.
DR HGNC; HGNC:10902; SLA.
DR VEuPathDB; HostDB:ENSG00000155926; -.
DR GeneTree; ENSGT00940000159104; -.
DR HOGENOM; CLU_084503_1_1_1; -.
DR OMA; SWRNIHR; -.
DR ChiTaRS; SLA; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000155926; Expressed in cortical plate and 179 other cell types or tissues.
DR ExpressionAtlas; E5RJ69; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR CDD; cd12010; SH3_SLAP; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035596; SLAP_SH3.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR PANTHER; PTHR46037:SF5; SRC-LIKE-ADAPTER; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:E5RJ69,
KW ECO:0007829|PeptideAtlas:E5RJ69};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 22..82
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 84..158
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT NON_TER 158
FT /evidence="ECO:0000313|Ensembl:ENSP00000430596.1"
SQ SEQUENCE 158 AA; 18106 MW; 46804E5B20EC9006 CRC64;
MGNSMKSTPA PAERPLPNPE GLDSDFLAVL SDYPSPDISP PIFRRGEKLR VISDEGGWWK
AISLSTGRES YIPGICVARV YHGWLFEGLG RDKAEELLQL PDTKVGSFMI RESETKKGFY
SLSVRHRQVK HYRIFRLPNN WYYISPRLTF QCLEDLVN
//
