ID E5S2L2_TRISP Unreviewed; 1119 AA.
AC E5S2L2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Exportin-1 {ECO:0000313|EMBL:KRY33798.1};
GN Name=Xpo1 {ECO:0000313|EMBL:KRY33798.1};
GN ORFNames=T01_2861 {ECO:0000313|EMBL:KRY33798.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY33798.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY33798.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY33798.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY33798.1}.
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DR EMBL; JYDH01000076; KRY33798.1; -; Genomic_DNA.
DR RefSeq; XP_003379413.1; XM_003379365.1.
DR AlphaFoldDB; E5S2L2; -.
DR STRING; 6334.E5S2L2; -.
DR EnsemblMetazoa; EFV60983; EFV60983; EFV60983.
DR GeneID; 10900353; -.
DR KEGG; tsp:Tsp_03075; -.
DR CTD; 10900353; -.
DR eggNOG; KOG2020; Eukaryota.
DR HOGENOM; CLU_011906_0_0_1; -.
DR InParanoid; E5S2L2; -.
DR OMA; WAFKHNN; -.
DR OrthoDB; 169519at2759; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR041123; CRM1_repeat.
DR InterPro; IPR041235; Exp1_repeat_2.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR045065; XPO1/5.
DR InterPro; IPR014877; XPO1_C_dom.
DR InterPro; IPR040485; XPO1_repeat_3.
DR PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR Pfam; PF08767; CRM1_C; 1.
DR Pfam; PF18777; CRM1_repeat; 1.
DR Pfam; PF18784; CRM1_repeat_2; 1.
DR Pfam; PF18787; CRM1_repeat_3; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM01102; CRM1_C; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 43..109
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT COILED 1045..1093
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1119 AA; 128059 MW; C4D2FF4800FCC03B CRC64;
MAEEILVKAS KLLEFNTPVI DVSLLDAVIN LMYCGTGEIQ RKAQEILTML KENNEAWTRV
DAVLEYSRSL QSKYFALQIL ENLVNTRWRR LPRDQCDGIK KYLVDRIISI SSNPSLSEDE
KVFLNKMNMV LVQIVKREWP KHWPTFISDI VGSSRSNESL CRNNMVILKL LSEEVFDFSS
GQMTQTKANH MKQQFCSEFR AIFELCQHIL ESSTNVMLVE ATLNTLLGFL VWIPVGYIFE
TNLIESLTAK FLSILPFRNV TLMCLTEIAG VTFPKNAPPA YSSTICRLFS RTMQQLNTVR
LNMLPPHTNI PEAYAMGNDN DQKCISNLAL FLSTILRQHC KIIEAECKEK IGELLGTPFD
LAMNYLLAIS EVDDMEVFKI CLDYWNWLVA ELYREPPLTN PLLTMNLAIQ LIRKDSLCTR
YHYVPYLSRL RSVIISRMAK PEEVLVVEND EGEVVRETIM DTDAISLYRT MRETLVYLTH
LDCADTERIM TEKLQNQTNG SEWSWKNLNC LCWAIGSISG ALMEEDEKRF LVMVIRDLLG
LCEQKRGKEN KAVIASNIMY VVGQYPRFLR AHWKFLKTVI NKLFEFMHET HEGVQDMACD
TFIKIANKCR RHFVIIQAGE KEPFIEEILA SLNTIICDLS PAQVHVFYEA VGYTISAQPV
QIVRDNLIER LMSLPNHTWD DVILKATTNV EILKDIEVVK NLVNILKTNS AACRSIGYPF
LPQLCRIYLD MLNVYKVTSE NINSAVTLHG ESVLKQPLIK CMRAVKTEVL RLINTWISTL
SSISESARIP ELPSIYMSFV PPLFDTVLFD YQRNVPSARE PEVLSACTVL ITQMKEKVSE
DVPKILDALF GCTLEMINKD FEDFPEHRIN FFQFIRSIIV NCFTGNIEEL KKKPLMLIPP
AQFTLIVDAI VWAFKHTTRN ITEIGLEILD RLLDSFSTKV SPDMAQSFYQ QYYLTILSHL
LSVVTDSTMA QVAGLTVFAV TLGRMFRELE EGLIKVPLQG PGQVKSNVEY VLEYTFELLK
KAFPHLTDEQ VRIIVQGILS YDNDVEKLKE HLRDFLVQIK EYTGEDTSDL YLAEKEQEVK
AAMEAKRRAA EAVPGILNPH EISEEMIEEP MGNGPALNA
//
