ID E5S7S9_TRISP Unreviewed; 260 AA.
AC E5S7S9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN Name=eIF6 {ECO:0000313|EMBL:KRY36675.1};
GN Synonyms=EIF6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN ORFNames=T01_3077 {ECO:0000313|EMBL:KRY36675.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY36675.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY36675.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY36675.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC association with the 40S ribosomal subunit to form the 80S initiation
CC complex in the cytoplasm. May also be involved in ribosome biogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_03132}.
CC -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC {ECO:0000256|HAMAP-Rule:MF_03132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}. Note=Shuttles
CC between cytoplasm and nucleus/nucleolus. {ECO:0000256|HAMAP-
CC Rule:MF_03132}.
CC -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC Rule:MF_03132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY36675.1}.
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DR EMBL; JYDH01000041; KRY36675.1; -; Genomic_DNA.
DR RefSeq; XP_003381243.1; XM_003381195.1.
DR AlphaFoldDB; E5S7S9; -.
DR STRING; 6334.E5S7S9; -.
DR EnsemblMetazoa; EFV59141; EFV59141; EFV59141.
DR GeneID; 10903685; -.
DR KEGG; tsp:Tsp_07767; -.
DR CTD; 10903685; -.
DR eggNOG; KOG3185; Eukaryota.
DR HOGENOM; CLU_071894_0_0_1; -.
DR InParanoid; E5S7S9; -.
DR OMA; LCHPKAT; -.
DR OrthoDB; 5473211at2759; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042256; P:cytosolic ribosome assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd00527; IF6; 1.
DR HAMAP; MF_00032; eIF_6; 1.
DR InterPro; IPR002769; eIF6.
DR NCBIfam; TIGR00323; eIF-6; 1.
DR PANTHER; PTHR10784; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR PANTHER; PTHR10784:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR Pfam; PF01912; eIF-6; 1.
DR PIRSF; PIRSF006413; IF-6; 1.
DR SMART; SM00654; eIF6; 1.
DR SUPFAM; SSF55909; Pentein; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03132}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03132}; Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
SQ SEQUENCE 260 AA; 27977 MW; DF432F29B01C20F2 CRC64;
MAVRAQYGNS YEIGVFAKLT NTYCLVGIGG CTNFYSVFEA ELDDVMPVVH ASVGGCRIVG
RLTVGNRHGL LVPMSTTDQE LQHLANSLPD NVKIRRVEER LSALGNVISC NDYAAVVHPE
LDYETEEALT DVLGVEVFRL TVAKNSLVGT YTVLSNQGGL VHPNATMQEL AELSSLLDIP
VASGSVNLGS SLIAGGLCVN DWCAFCGMNT SATEIGVIES IFKIGLKGPQ QMSSELQIHS
RNANFNVLSY MNARLQDLTM
//
