ID E5SRA2_TRISP Unreviewed; 417 AA.
AC E5SRA2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Splicing factor 45 {ECO:0000256|PIRNR:PIRNR031066};
DE AltName: Full=RNA-binding motif protein 17 {ECO:0000256|PIRNR:PIRNR031066};
GN Name=RBM17 {ECO:0000313|EMBL:KRY33935.1};
GN ORFNames=T01_12702 {ECO:0000313|EMBL:KRY33935.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY33935.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY33935.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY33935.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Splice factor that binds to the single-stranded 3'AG at the
CC exon/intron border and promotes its utilization in the second catalytic
CC step. Involved in the regulation of alternative splicing and the
CC utilization of cryptic splice sites. {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBUNIT: Associates with the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY33935.1}.
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DR EMBL; JYDH01000075; KRY33935.1; -; Genomic_DNA.
DR RefSeq; XP_003371372.1; XM_003371324.1.
DR AlphaFoldDB; E5SRA2; -.
DR STRING; 6334.E5SRA2; -.
DR EnsemblMetazoa; EFV52683; EFV52683; EFV52683.
DR GeneID; 10903035; -.
DR KEGG; tsp:Tsp_11979; -.
DR CTD; 10903035; -.
DR eggNOG; KOG1996; Eukaryota.
DR HOGENOM; CLU_044888_0_1_1; -.
DR InParanoid; E5SRA2; -.
DR OMA; IMSKFGY; -.
DR OrthoDB; 1343740at2759; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd12647; RRM_UHM_SPF45; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040052; RBM17.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034653; SPF45_RRM.
DR PANTHER; PTHR13288:SF8; SPLICING FACTOR 45; 1.
DR PANTHER; PTHR13288; SPLICING FACTOR 45 SPF45; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF031066; Splicing_factor_SPF45; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW mRNA processing {ECO:0000256|PIRNR:PIRNR031066};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR031066};
KW Nucleus {ECO:0000256|PIRNR:PIRNR031066};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR031066, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Spliceosome {ECO:0000256|PIRNR:PIRNR031066};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..296
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 324..408
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 91..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 46839 MW; 5C96EE135B6FF641 CRC64;
MFENNTLFIF CVTVIAIVYP ICMQVCKVEQ CRYTMVWIHL WQEFLIQMKR THANRPFPKA
CIIFHIAHES WKKNLKLLKA HMHLKRVAAL QKVRPPPSDE QHQGMSTLSK AGNKNSGSSV
GSAMHSSLAK QQAVSVQDEW RVEDEYDPNH PNEFANLVTF RDNARSKFGC QSYTRRSGVE
KTNYSSSGDE VGEEEKPIGK WNSLCERPER WRSTGAAIAP PPELIEQDKQ TAVSESETSD
SSFMPPPPPP TASARGLDFA ARIMERYGYK QGSGLGRDEQ GMSTALQVEK VGTRHGKIIH
ESSSAATAST TEVNVTDELR NPTKVMLLRN MVGAGEVDSE LQPEVQDEML KYGEVRRCMV
VEVPNASDVD AVRIFVEFAR VEQAIKAVVA LNGRFFAGRS VMASFYDPEK FARLELY
//