ID E5WHA6_9BACI Unreviewed; 293 AA.
AC E5WHA6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Nucleoid occlusion protein {ECO:0000256|HAMAP-Rule:MF_02015};
DE Short=Noc {ECO:0000256|HAMAP-Rule:MF_02015};
GN Name=noc {ECO:0000256|HAMAP-Rule:MF_02015};
GN ORFNames=HMPREF1013_01838 {ECO:0000313|EMBL:EFV77966.1};
OS Bacillus sp. 2_A_57_CT2.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=665959 {ECO:0000313|EMBL:EFV77966.1, ECO:0000313|Proteomes:UP000003283};
RN [1] {ECO:0000313|EMBL:EFV77966.1, ECO:0000313|Proteomes:UP000003283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2_A_57_CT2 {ECO:0000313|EMBL:EFV77966.1,
RC ECO:0000313|Proteomes:UP000003283};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Larson L., Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacillus sp. strain 2_A_57_CT2.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Effects nucleoid occlusion by binding relatively
CC nonspecifically to DNA and preventing the assembly of the division
CC machinery in the vicinity of the nucleoid, especially under conditions
CC that disturb the cell cycle. It helps to coordinate cell division and
CC chromosome segregation by preventing the formation of the Z ring
CC through the nucleoid, which would cause chromosome breakage.
CC {ECO:0000256|HAMAP-Rule:MF_02015}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000256|HAMAP-
CC Rule:MF_02015}.
CC -!- SIMILARITY: Belongs to the ParB family. {ECO:0000256|ARBA:ARBA00006295,
CC ECO:0000256|HAMAP-Rule:MF_02015}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV77966.1}.
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DR EMBL; ACWD01000026; EFV77966.1; -; Genomic_DNA.
DR RefSeq; WP_009332483.1; NZ_GL635751.1.
DR AlphaFoldDB; E5WHA6; -.
DR eggNOG; COG1475; Bacteria.
DR HOGENOM; CLU_023853_0_1_9; -.
DR Proteomes; UP000003283; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR CDD; cd16393; SPO0J_N; 1.
DR Gene3D; 1.10.10.2830; -; 1.
DR Gene3D; 3.90.1530.30; -; 1.
DR HAMAP; MF_02015; ParB_Noc; 1.
DR InterPro; IPR041468; HTH_ParB/Spo0J.
DR InterPro; IPR023705; Nucleoid_occlusion_protein.
DR InterPro; IPR004437; ParB/RepB/Spo0J.
DR InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR NCBIfam; TIGR04285; nucleoid_noc; 1.
DR NCBIfam; TIGR00180; parB_part; 1.
DR PANTHER; PTHR33375; CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED; 1.
DR PANTHER; PTHR33375:SF8; NUCLEOID OCCLUSION PROTEIN; 1.
DR Pfam; PF17762; HTH_ParB; 1.
DR Pfam; PF02195; ParBc; 1.
DR SMART; SM00470; ParB; 1.
DR SUPFAM; SSF109709; KorB DNA-binding domain-like; 1.
DR SUPFAM; SSF110849; ParB/Sulfiredoxin; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_02015};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_02015};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_02015};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_02015}; Reference proteome {ECO:0000313|Proteomes:UP000003283};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_02015}.
FT DOMAIN 40..130
FT /note="ParB/Sulfiredoxin"
FT /evidence="ECO:0000259|SMART:SM00470"
FT DNA_BIND 156..175
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02015"
SQ SEQUENCE 293 AA; 33592 MW; E2F4981B0F2AA051 CRC64;
MKHSFSRFFG LGEKGEQVTA EKPAEEQLDI EDLSDREEVK KIPIDQIVPN RFQPRTVFDD
EKIEELSRTI HTHGIIQPIV VREFEDGQFE IIAGERRYRA MKKLGWEEAP AIVKNLSDTE
TASVALIENL QREELSPIEE AVAYGKLLEL HNLTQEALAQ RLGKGQSTVA NKLRLLKLPQ
PVQDALLNKS ITERHARSLI PLKDPEKQVA LLQEIVEKNL NVKQTEDRVV KILEQKNPKP
KPKRKAFSKD MRIAVNTIRQ SLSMVSDSGI NLDSEEEEFD EFYQITIKIP KKK
//
