ID E5WX23_9BACE Unreviewed; 702 AA.
AC E5WX23;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=HMPREF1016_01225 {ECO:0000313|EMBL:EFV30565.1};
OS Bacteroides eggerthii 1_2_48FAA.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=665953 {ECO:0000313|EMBL:EFV30565.1, ECO:0000313|Proteomes:UP000003246};
RN [1] {ECO:0000313|EMBL:EFV30565.1, ECO:0000313|Proteomes:UP000003246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1_2_48FAA {ECO:0000313|EMBL:EFV30565.1,
RC ECO:0000313|Proteomes:UP000003246};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Young S.K., Gargeya S., Zeng Q.,
RA Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C.,
RA Allen-Vercoe E., Ambrose C., Strauss J., Daigneault M., Haas B.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroides eggerthii strain 1_2_48FAA.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV30565.1}.
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DR EMBL; ACWG01000013; EFV30565.1; -; Genomic_DNA.
DR RefSeq; WP_004293554.1; NZ_GL622540.1.
DR AlphaFoldDB; E5WX23; -.
DR GeneID; 66250662; -.
DR HOGENOM; CLU_392643_0_0_10; -.
DR Proteomes; UP000003246; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..176
FT /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT /evidence="ECO:0000259|Pfam:PF07733"
FT DOMAIN 181..346
FT /note="DNA polymerase III alpha subunit finger"
FT /evidence="ECO:0000259|Pfam:PF17657"
FT DOMAIN 420..487
FT /note="DNA polymerase helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF14579"
SQ SEQUENCE 702 AA; 79446 MW; E703605CDA279230 CRC64;
MWRADIPPSR KADIDVDYAS DRRQEIKDYL EERYNADGRQ RVFSAGTFTT MKLKAALKDV
ARVHRVPHSI VNYITAMIDD GTDWTGLFRQ AASNRKLRDF IQTYPLVIED VQGLLGQPKA
ASIHASAIVV TPDTRDGRPA ECFDFLPVRK MDGALVSEFD GYSVDEIGLL KEDVLATKEL
AKLSAVIALV NRNFGQELTI GRITQDMLED GKTYRLLSDG NTQNVFQFSS PGITRFIQDV
QPECIEDLIA VNALYRPATL DIGATDDYVR FRRGEVAPVY NYGCYEATKN TFGIMVYQEQ
FMSVAHTLGG FDLGKTDLLR KAIGKKKADL MATLKADFIA GAVGNGCPDY EAEEIWHKIE
VAGKYSFNRS HAAAYALTAY CGAWLKANYP SAFYTVALQW ADDKEIPSLM AEMERCSPAK
IVPPDINRSG TEFFTDYATD EIFWSLTRIK QVGLRTVEYI VTERDRGGAY TGIENFIHRI
FRYKLKKYSY WDDPDNAEEA VKVPVNARHV KHMILAGCFD RIEKVGAVTE RCALLERAAR
ELGFSLSEKD FPQDMRGRHF FWSQQQIAVS GIGSIDYRRI FDNSEASGQV KGKASYLTLD
EVARDENDGR RAAVCATVVD VAEHTYKDRE TGSRKRFARL TLSQNNRLAE CVCWNDYYME
HRTEIQSLKD RVVILTAVIR YSDYNGCNTL QTYKNSLLFI QS
//
