GenomeNet

Database: UniProt
Entry: E5Y7S6_BILWA
LinkDB: E5Y7S6_BILWA
Original site: E5Y7S6_BILWA 
ID   E5Y7S6_BILWA            Unreviewed;       437 AA.
AC   E5Y7S6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   28-FEB-2018, entry version 33.
DE   SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating)(NADP+) {ECO:0000313|EMBL:EFV43942.1};
GN   ORFNames=HMPREF0179_02241 {ECO:0000313|EMBL:EFV43942.1};
OS   Bilophila wadsworthia 3_1_6.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Bilophila.
OX   NCBI_TaxID=563192 {ECO:0000313|EMBL:EFV43942.1, ECO:0000313|Proteomes:UP000006034};
RN   [1] {ECO:0000313|EMBL:EFV43942.1, ECO:0000313|Proteomes:UP000006034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_6 {ECO:0000313|EMBL:EFV43942.1,
RC   ECO:0000313|Proteomes:UP000006034};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Young S.K., Gargeya S., Zeng Q.,
RA   Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Mehta T., Neiman D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Allen-Vercoe E., Sibley C., Ambrose C.E.,
RA   Strauss J., Daigneault M., Haas B., Nusbaum C., Birren B.;
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFV43942.1, ECO:0000313|Proteomes:UP000006034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_6 {ECO:0000313|EMBL:EFV43942.1,
RC   ECO:0000313|Proteomes:UP000006034};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Sibley C., Strauss J.,
RA   Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Bilophila wadsworthia 3_1_6.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003427}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFV43942.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADCP02000001; EFV43942.1; -; Genomic_DNA.
DR   RefSeq; WP_005028058.1; NZ_KE150238.1.
DR   STRING; 563192.HMPREF0179_02241; -.
DR   EnsemblBacteria; EFV43942; EFV43942; HMPREF0179_02241.
DR   eggNOG; ENOG4105C6K; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   OrthoDB; POG091H02AU; -.
DR   BioCyc; BWAD563192-HMP:GMAG-2271-MONOMER; -.
DR   Proteomes; UP000006034; Unassembled WGS sequence.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006034};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003427};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006034}.
FT   DOMAIN       18    151       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      163    399       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE     39     39       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE     94     94       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       136    136       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       137    137       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       162    162       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   437 AA;  47473 MW;  E892AEFC22BF57B9 CRC64;
     MALFTREEAL EYHRSPRHGK TEVVLTKRCE SQKDLSLAYS PGVAEACKAI AEDQALVSEY
     TGRANLVAVI SDGTAVLGLG NIGPYAAKPV MEGKGVLFKN FADVDVFDLC LKTGSTEEFI
     AAVRTMEPTF GGINLEDIKA PECFIIEETL KKEMGIPVFH DDQHGTAIIS GAALLNACEL
     TGRRIEDVTV VVVGAGAAGM ACARFYCALG VKRGNIRMFD SKGLIHKKRS NLAEYKLEFA
     QEEDLGSLAD CMKGTDLFLG LSTKNLVSQD MVRSMADKPV LFAMANPDPE ISYEDAKAAR
     PDCIMGTGRS DYPNQINNVS GFPYIFRGAL DVEATEINEA MKIAAAEALA ALAKEPVPAE
     VCSAYNVDSL EYGFDYIIPK PLDPRILTCI TPAVAKAAMD TGVARKRIED LDGYARELER
     RVKASHDRIR PFVASYE
//
DBGET integrated database retrieval system