ID E6KWM2_9PAST Unreviewed; 1919 AA.
AC E6KWM2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Alpha-2-macroglobulin family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9064_0566 {ECO:0000313|EMBL:EFU67903.1};
OS Aggregatibacter segnis ATCC 33393.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Aggregatibacter.
OX NCBI_TaxID=888057 {ECO:0000313|EMBL:EFU67903.1, ECO:0000313|Proteomes:UP000032871};
RN [1] {ECO:0000313|EMBL:EFU67903.1, ECO:0000313|Proteomes:UP000032871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33393 {ECO:0000313|EMBL:EFU67903.1,
RC ECO:0000313|Proteomes:UP000032871};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU67903.1}.
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DR EMBL; AEPS01000003; EFU67903.1; -; Genomic_DNA.
DR RefSeq; WP_006717492.1; NZ_LS483443.1.
DR STRING; 739.GCA_001059425_01697; -.
DR GeneID; 60799966; -.
DR HOGENOM; CLU_000965_2_0_6; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000032871; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000032871}.
FT DOMAIN 1018..1157
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1228..1318
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1919 AA; 213467 MW; 06FACFC24B7F3786 CRC64;
MQDKTKFSVL GALVLAIAAG GGSYWYQQQK GNENNAVHVK FNPIEPTYYG EEGTSNTVYP
LNIEFNGAAA PIDKLKTEIT QGIKMEPALE GRWVWSSDNL LSFTPAQDWP TGQEYKITLD
KTALNPGLTY AKSVTTPHSV KTQPFSVVDS DADFYQDPNV FHVRHALTHL VFSNPVDPKA
LESAVEVNLV RKNQDQSLNL INPLKFKIRY SDNKLEAWIS SDDLSLSTQP NQFVQTKISQ
TLRAKTGVNT LDKDITKLVP VPTKYSLQNE DNSFKVINNQ QNEAEQVLTF NFNYGVKGKD
IAENLIAILL PALPEGQSWE SEKLTEAAVR RGERVQPELI PSEHPYSAQQ SFRFDIPEGR
CLYLQLNNKF TALGGYQLKK PIGSLECAPN YPTYVGFVGK GSLLSQYGDG KLTLAVRNAD
SVQLDIGRVQ AEQLRHVANL NSNSFQKPDL GNLKFDDIAT FKTETLTVAN DNPRKSDYLS
VDLSQKGLPK QGIFWVKASA VSSGSESDGD NLKDSKDEDG YYYWNSDPDS QTSDYRLIVL
TDLGIIAKKA ADGTQSVFVQ SIASGAPVSN ALVKVISRNN TVIASQFTNK LGVAQLPSLE
NFKQELEPVM YLVTRGQDQS FLPIDKSDRT LDFSRFDIRG QEISPEQNAI KTFLFNDRGI
YRPGESVYIG MISKALDWKK SLANVPLTLE ITSPSGKTQW QKTIRVSESG FNDLTYPLSE
NAETGEWTAH ISIGQQQEQI DVGSMTFQVQ EFEPDTLKIN TMFNRSQQAG WVSPQDLKAT
IHLTNLFGTP AQKRRVSANI MLHSLFPSFP EYKNYQFYDN QRNKNAILLE TELQDQTTDN
NGDAVFALNL AQEAENTVQM LYFTADGYEN NSGRGVSKVQ SVLVSAQPWL VGYSSAQDLS
YLRENGVSQV NLIAINPSLQ KISVQGLSAV LMERKYVSVL TEQRSGAYKY ESKLVENQID
EKPLDIDQSG SDFVLNTEHS GDFVLVINNQ YGETVNRIPY TVIGNSNVSV AMDKNTELKL
NLNKKQFMPG EEIEVAINAP YAGSGLITIE RDRVYAHQWF KSTTNRSVQK IRIPENFEGS
GYINVQFSRD MQSDDIFTSP LSYGVAPFSV NVDNHRLNVT LNVPQQVKSG DKVQFTLSSD
KPSKAVIYAV NEGILQVAGH KQEDPLKFFF PKYALQVETL QILDLILPEF RKVLQFAQTG
GDSEEMAMLE KALAANTNPF KRKTDKPAVF WSNIVDVDGS KTVTYQIPSG FNGNLKVMAV
AVTNDGSQMN IAQAETLVRD DMILSPSAPI TLAPNDESKV SLTVSNNTKS KQNVLVQLNV
APQFQVLSNA QTSIVLAPMS EGVVDFQLKA TDLLGSGILY FTAAYLDELQ QPAQVERKYG
ISVRPLTAKQ QFIKVGDVAA NQQVQGELPN LLFPQRREQY ALISSAPLVL AKGITSYLGN
YDNFCTEQII SAAMPNLLLA NNPEYQSLLG VLSQAGDKQA IEATKQQLHN NLNRVFNLLP
ARQTENEGFG VWSGLDEDDA FLTAYVAHFL IEAQEHNVQL PAAWIAPNGL FNQTIAALER
LSRPESEDNL AMLRQRAYAT YLLARLGQVP SDSLMSIRSL LERHFKAEEW QSDLAAAWLA
GAYQLVKQDE DANTLMNNLM ANFAHPQAKS EWFYRDYLDP LIEKSSVLYV LSRHFPKQAA
LLSNGLFEGI VQDLNDDRYN SLSSAMVLLA LEAYGKQYPD QLEKLHIQQE GQNIGGVQGS
FVLANINADK AALNFVNQST QRAWYAISQS GYVQQPSAEA IKNGVEIDRT YLDKDGKPVS
SVKLGDIINV QVNVRSLQNV QDNMVITDLY PAGFEVVTGN GDMSAQEETQ QRFNWVHRDL
REDRMLSYGS VGETTTVIQY QLKAVNVGKF KIPQAYAENM YNRAVNAQSA AKGDIEVIQ
//
