ID E6LGP7_ENTI1 Unreviewed; 605 AA.
AC E6LGP7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=TrkA C-terminal domain protein {ECO:0000313|EMBL:EFU73658.1};
GN ORFNames=HMPREF9088_1537 {ECO:0000313|EMBL:EFU73658.1};
OS Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=888064 {ECO:0000313|EMBL:EFU73658.1, ECO:0000313|Proteomes:UP000010296};
RN [1] {ECO:0000313|EMBL:EFU73658.1, ECO:0000313|Proteomes:UP000010296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5
RC {ECO:0000313|Proteomes:UP000010296};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU73658.1}.
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DR EMBL; AEPV01000064; EFU73658.1; -; Genomic_DNA.
DR RefSeq; WP_007208550.1; NZ_JXKT01000009.1.
DR AlphaFoldDB; E6LGP7; -.
DR STRING; 888064.HMPREF9088_1537; -.
DR GeneID; 84700434; -.
DR PATRIC; fig|888064.11.peg.2307; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0569; Bacteria.
DR HOGENOM; CLU_030184_0_0_9; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000010296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR43562:SF1; NA(+)_H(+) ANTIPORTER YJBQ-RELATED; 1.
DR PANTHER; PTHR43562; NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010296};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 389..499
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 520..603
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 605 AA; 67456 MW; 005F9CEDBB82DE8E CRC64;
MSLLIVLFAA LMIPLAMARF KITAVPTAIA EIIVGIIIGR TGFQFVETTN NLSFLSSLGV
IILIFLSGME IDFSLFKTKT SEEKGTQPLP MAILSFVAIL GTSVLLAFVV KFLGIFDNLM
LSTILFSTIA LGVVIAALKE KELLSKPYGQ TLLLIAVLGE IIPLLALSAY AALNGGQSEQ
IWLILVIFLV AILLLWRFRG IYDFFAKVDK STTQLDIRLA FFIVFTLVTV AETVGAENIL
GAFLAGIVMK LLQPSESTQE KLTSVGYGFF IPVFFIMTGA KLELRSLLIQ PEAWLMILLL
FVCFMVAKAG LFFTMQKSFN RTNALAGACI SATTITLVLP TLEVAAHLDQ ITEVQVGEFT
LAAVLCCILA PIFFNKFYQS TEEEEQLTKV TFFGTNVLTI PVAQQLAKGW YDIQMVTDDR
EHYETFRSAM DHVLFLENRE EQTLFDKQIF DADVLVLGYR DDAINYEMAQ LAAKYEVPRV
IVRLESHDLT DTKYEQLQAK GAELFNTFDV NISLLREMID SPSTLKMLTD TESGLYEVSV
NNRRYTGIPI KSLPFIEAIT ISRIYRNNEF IAPRGNTVIE LGDHLIFTGN KETVKELRHV
LSLTN
//
