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Database: UniProt
Entry: E6MLV8_9BACT
LinkDB: E6MLV8_9BACT
Original site: E6MLV8_9BACT 
ID   E6MLV8_9BACT            Unreviewed;       823 AA.
AC   E6MLV8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   26-FEB-2020, entry version 50.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   Name=feoB {ECO:0000313|EMBL:EFV05384.1};
GN   ORFNames=HMPREF9420_0475 {ECO:0000313|EMBL:EFV05384.1};
OS   Prevotella salivae DSM 15606.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=888832 {ECO:0000313|EMBL:EFV05384.1, ECO:0000313|Proteomes:UP000003874};
RN   [1] {ECO:0000313|EMBL:EFV05384.1, ECO:0000313|Proteomes:UP000003874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15606 {ECO:0000313|EMBL:EFV05384.1,
RC   ECO:0000313|Proteomes:UP000003874};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFV05384.1}.
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DR   EMBL; AEQO01000048; EFV05384.1; -; Genomic_DNA.
DR   RefSeq; WP_007133755.1; NZ_GL629647.1.
DR   STRING; 888832.HMPREF9420_0475; -.
DR   EnsemblBacteria; EFV05384; EFV05384; HMPREF9420_0475.
DR   eggNOG; ENOG4105CE1; Bacteria.
DR   eggNOG; COG0370; LUCA.
DR   eggNOG; COG1918; LUCA.
DR   HOGENOM; CLU_013350_3_0_10; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; GCF_000185845-HMP:HMPREF9420_RS02155-MONOMER; -.
DR   Proteomes; UP000003874; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   Pfam; PF04023; FeoA; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SMART; SM00899; FeoA; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        469..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        580..600
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        642..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        765..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        796..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   DOMAIN          119..281
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51711"
SQ   SEQUENCE   823 AA;  92449 MW;  54836A5F4E64FA1F CRC64;
     MKLSELKTGE HGVIVKVIGH GSFRKRIVEM GFIKGKMVKV LLNAPLMDPV KYKIMGYEVS
     LRRSEAEMIE VVSESEIKTI KASQSHENKE INTQEDDSSI DDIPTEKQLE KIAQERHKII
     NVALVGNPNC GKTSLFNFAS GAHEHVGNYS GVTVDAKVGH AEFEGYTFNL VDLPGTYSLS
     AYSPEELYVR KQIIDETPDI VINVIDASNL ERNLYLTTQL IDMNLNMVCA LNMFDETKKR
     GDKIDLNKLS TLFGVPMIPT VFKTGEGVKE LFHQVIKLYE NNGEEHPYVR HIHINHGHEI
     ENGIQNIQKY LKNDVNVRQK YSTRYLAIKL LENDADTIKY IQTLSNAEAI FKAREYAEAR
     VKEETGEDCE TTIMDAKYGF IHGALEEALY ETGKNKDIYQ MTQSIDRVIT NRYLGFPIFI
     LVLFIMFSAT FIIGQIPMDW IDAAVAWFGK MISQNLPDGP IKAMLVDGVI GGVGAVIVFL
     PQILILYFFI SFMEDSGYMA RAAFIMDKLM HKMGLHGKSF IPLIMGFGCN VPAVMSTRTI
     ESRRSRLITM LILPLMSCSA RLPIYIMITG SFFALKYQSL VMLSLYVIGI TISIILSRIF
     SKFVVKGEDT PFVMELPPYR FPTWKAMGRH TWEKGKQYLK KMGGIILVAS IIVWALGYFP
     HDDSLSPQQQ QEQSYIGKIG KTVEPVFLAQ GFDWKIDVGL LSGVGAKEIV ASTMGVLYSN
     DSSFSEDNKF NDAGGKYQAL RRQMTHDIAR LHGISDIEAA PIATLTAYCF LLFVLLYFPC
     IATIAAIKGE TGSWKWALFA AGYTTMLAWG VSAVVYQIGR LFI
//
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