ID E6N6B6_CALS0 Unreviewed; 317 AA.
AC E6N6B6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:BAJ47835.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:BAJ47835.1};
GN ORFNames=CSUB_C0805 {ECO:0000313|EMBL:BAJ50663.1}, HGMM_F52H05C45
GN {ECO:0000313|EMBL:BAJ47835.1};
OS Caldiarchaeum subterraneum.
OC Archaea; Nitrososphaerota; Candidatus Caldarchaeales;
OC Candidatus Caldarchaeaceae; Candidatus Caldarchaeum.
OX NCBI_TaxID=311458 {ECO:0000313|EMBL:BAJ47835.1, ECO:0000313|Proteomes:UP000008120};
RN [1] {ECO:0000313|EMBL:BAJ47835.1, ECO:0000313|Proteomes:UP000008120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16309394; DOI=10.1111/j.1462-2920.2005.00881.x;
RA Nunoura T., Hirayama H., Takami H., Oida H., Nishi S., Shimamura S.,
RA Suzuki Y., Inagaki F., Takai K., Nealson K.H., Horikoshi K.;
RT "Genetic and functional properties of uncultivated thermophilic
RT crenarchaeotes from a subsurface gold mine as revealed by analysis of
RT genome fragments.";
RL Environ. Microbiol. 7:1967-1984(2005).
RN [2] {ECO:0000313|EMBL:BAJ47835.1, ECO:0000313|Proteomes:UP000008120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21169198; DOI=10.1093/nar/gkq1228;
RA Nunoura T., Takaki Y., Kakuta J., Nishi S., Sugahara J., Kazama H.,
RA Chee G., Hattori M., Kanai A., Atomi H., Takai K., Takami H.;
RT "Insights into the evolution of Archaea and eukaryotic protein modifier
RT systems revealed by the genome of a novel archaeal group.";
RL Nucleic Acids Res. 39:3204-3223(2011).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; AP011847; BAJ47835.1; -; Genomic_DNA.
DR EMBL; BA000048; BAJ50663.1; -; Genomic_DNA.
DR AlphaFoldDB; E6N6B6; -.
DR STRING; 311458.CSUB_C0805; -.
DR KEGG; csu:CSUB_C0805; -.
DR BioCyc; CCAL311458:G131R-818-MONOMER; -.
DR Proteomes; UP000008120; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:BAJ47835.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008120}.
FT DOMAIN 4..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..289
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 144
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 317 AA; 35472 MW; 8634104F4B2A8751 CRC64;
MDFVDVIGAG RIGHGIALCV AMHGFRVRLR DVKHRTPDER KMLQEKIFSQ IRESLRLFEE
CEFIHESVEE VVRRIVFVDG YDGLEDAFHV VEAVPEDAAV KKQVYGMVSE RIGGDVLLAS
TSSSMRPSAL AKHVKHPERF LVTHWINPAE LIPLVEVAPS PQTSRETVEE AVEFLRRCGK
RPVVCGDSPG YVSARLQAAL MNEALRLVEE GVASPRDVDE ALMAGIGFRL SVHGLLEFVD
WGGVDILYRV DEYLAAELKA ERFKPPALLR KLVEKGCLGM HVGRGVFDYS GVDTEALKLS
RKKAMVKRLK QLRDEQG
//
