ID E6N7L5_CALS0 Unreviewed; 256 AA.
AC E6N7L5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA polymerase sliding clamp {ECO:0000256|HAMAP-Rule:MF_00317};
DE AltName: Full=Proliferating cell nuclear antigen homolog {ECO:0000256|HAMAP-Rule:MF_00317};
DE Short=PCNA {ECO:0000256|HAMAP-Rule:MF_00317};
GN Name=pcn {ECO:0000256|HAMAP-Rule:MF_00317};
GN ORFNames=CSUB_C1233 {ECO:0000313|EMBL:BAJ51084.1}, HGMM_F31B05C20
GN {ECO:0000313|EMBL:BAJ48284.1};
OS Caldiarchaeum subterraneum.
OC Archaea; Nitrososphaerota; Candidatus Caldarchaeales;
OC Candidatus Caldarchaeaceae; Candidatus Caldarchaeum.
OX NCBI_TaxID=311458 {ECO:0000313|EMBL:BAJ48284.1, ECO:0000313|Proteomes:UP000008120};
RN [1] {ECO:0000313|EMBL:BAJ48284.1, ECO:0000313|Proteomes:UP000008120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16309394; DOI=10.1111/j.1462-2920.2005.00881.x;
RA Nunoura T., Hirayama H., Takami H., Oida H., Nishi S., Shimamura S.,
RA Suzuki Y., Inagaki F., Takai K., Nealson K.H., Horikoshi K.;
RT "Genetic and functional properties of uncultivated thermophilic
RT crenarchaeotes from a subsurface gold mine as revealed by analysis of
RT genome fragments.";
RL Environ. Microbiol. 7:1967-1984(2005).
RN [2] {ECO:0000313|EMBL:BAJ48284.1, ECO:0000313|Proteomes:UP000008120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21169198; DOI=10.1093/nar/gkq1228;
RA Nunoura T., Takaki Y., Kakuta J., Nishi S., Sugahara J., Kazama H.,
RA Chee G., Hattori M., Kanai A., Atomi H., Takai K., Takami H.;
RT "Insights into the evolution of Archaea and eukaryotic protein modifier
RT systems revealed by the genome of a novel archaeal group.";
RL Nucleic Acids Res. 39:3204-3223(2011).
CC -!- FUNCTION: Sliding clamp subunit that acts as a moving platform for DNA
CC processing. Responsible for tethering the catalytic subunit of DNA
CC polymerase and other proteins to DNA during high-speed replication.
CC {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- FUNCTION: Sliding clamp subunit. Responsible for tethering the
CC catalytic subunit of DNA polymerase to DNA during high-speed
CC replication. {ECO:0000256|RuleBase:RU003673}.
CC -!- SUBUNIT: Homotrimer. The subunits circularize to form a toroid; DNA
CC passes through its center. Replication factor C (RFC) is required to
CC load the toroid on the DNA. {ECO:0000256|HAMAP-Rule:MF_00317}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|HAMAP-Rule:MF_00317, ECO:0000256|RuleBase:RU003671}.
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DR EMBL; AP011861; BAJ48284.1; -; Genomic_DNA.
DR EMBL; BA000048; BAJ51084.1; -; Genomic_DNA.
DR AlphaFoldDB; E6N7L5; -.
DR STRING; 311458.CSUB_C1233; -.
DR KEGG; csu:CSUB_C1233; -.
DR Proteomes; UP000008120; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.70.10.10; -; 1.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00317,
KW ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00317}; Reference proteome {ECO:0000313|Proteomes:UP000008120}.
FT DOMAIN 11..119
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 133..253
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 256 AA; 28258 MW; 87B443B66521EBE5 CRC64;
MSESQPTFKL TLPSADYFAS IVKAISAVVD EGSFTADSES LKLTGMDPAH VSLVNFVFNR
EAAEEYVCEK PVEIKVNISS LYKFLKRAGN ESLTIEYDED NKRLTIVFVN TAARKERRFV
MSTLEPGAGP TPIPKLTFDA KCRVDTAAFY EAVDDATIVS DYARIIIRPN ELVISSKSDV
QTHVTRLEKD GSLVHEISTD KEVSASFSLA YLEKIMSASK TLSDETGIEL STNKPIKLSF
PLTGGKIEFL IAPRLE
//
