ID E6QZ14_CRYGW Unreviewed; 764 AA.
AC E6QZ14;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=HSF-type DNA-binding domain-containing protein {ECO:0000259|SMART:SM00415};
GN OrderedLocusNames=CGB_A0610C {ECO:0000313|EMBL:ADV19343.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV19343.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV19343.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|RuleBase:RU004020}.
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DR EMBL; CP000286; ADV19343.1; -; Genomic_DNA.
DR RefSeq; XP_003191130.1; XM_003191082.1.
DR AlphaFoldDB; E6QZ14; -.
DR GeneID; 10188808; -.
DR KEGG; cgi:CGB_A0610C; -.
DR VEuPathDB; FungiDB:CGB_A0610C; -.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_350548_0_0_1; -.
DR OrthoDB; 1650781at2759; -.
DR Proteomes; UP000007805; Chromosome A.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10015:SF457; HSF_DOMAIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT DOMAIN 198..303
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00415"
FT REGION 18..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 83632 MW; 61ABF8F598FD06EC CRC64;
MNSFSCLLPP LRESKMALFQ PSSYPPPSAS PFGRLNLPHH TSSHHQHNDS SGSSYHPNNS
PPVSEGWLPK LPVSQSRAYV SPDPSPRDED AFLPHWGPHH PNVNQHAQSH SQSHQPRLPV
PVLAAYSTPP SMLKMQFPHH HELLASSDMT TGSGSVGDGG RHTGMGEGDM TPEMDPFYNP
TMPPPEQSSK KKKKAEGKQP TFLTKLYSVL SQPEYSHIIR WDEAGESVII ENPEELADKI
LPVVYRQSRF ASFSRQLNIY GFNRKLSLRN VEKGICDPDA SSWSHPFLRR DSTKEQILSF
KRRVPPRPSQ ARKRLMSMGL GVGINASYAG ASNGNDQVSP TSSEQSLDWQ SPPDPYQHHL
LSDVDEESPF VFPTRHYFSL AGYGSVGYEG WKQNGAASGS VQCLASQGEE GFSPTTVHFD
YGTPPDRDGL NGFMASSQVR YGGSPKGLAI NNPLSSHPFN HHTQQQVKPS LPLPCQPLPF
SLLGQKLSTN LIPQSAPANT GSFPIPIRVT QHHVRTRSVQ GEPPSAMLFS PFDGEMGEVP
EPAGFSQNLN GTKSHGHQRG TMDPPVIPAT PTYDPSDPST WARRGFIDFN AAGVSNPLPF
NPMSTYARLA TSPHSLPTDM STLHQQQTAS PSELMGQSIS SALSDDSPKM VPPGTYQSGF
LLPVCQSPYL QERISSLNPP ARTRSNPTPN LNSNAGFEKS PRMNNGHIVR PSPITQREHS
WTGMNGNWLR TIGSLSRSNE ENSSAVGESD VDGGERKQSE DFSP
//
