ID E6QZN9_CRYGW Unreviewed; 987 AA.
AC E6QZN9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Cation transporter, putative {ECO:0000313|EMBL:ADV20050.1};
GN OrderedLocusNames=CGB_B0030W {ECO:0000313|EMBL:ADV20050.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV20050.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV20050.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; CP000287; ADV20050.1; -; Genomic_DNA.
DR RefSeq; XP_003191837.1; XM_003191789.1.
DR AlphaFoldDB; E6QZN9; -.
DR GeneID; 10186879; -.
DR KEGG; cgi:CGB_B0030W; -.
DR VEuPathDB; FungiDB:CGB_B0030W; -.
DR eggNOG; ENOG502RX8H; Eukaryota.
DR HOGENOM; CLU_285315_0_0_1; -.
DR OrthoDB; 1358357at2759; -.
DR Proteomes; UP000007805; Chromosome B.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 3.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF90; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 886..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 108424 MW; 4EAF0975C281739E CRC64;
MPDSNTRTVV AIDYAPTPAR HPHSDSHRTP NSHPSPILTH RTPSAHPDVA QPEFAELLTP
LKFRRRKLQP RPDQQPTSLP LVAGPSDLGY YTLEGDLYRG SAYNPTQPPP AVAAQVDDDA
ISLGTKSTTS STSNWSWGSG NFDRAMAVIE RVGEALGVRR GSAGSSSSDS SADGSDMESL
KSQATAPKKG KKRRGSFMSS VSRQTSRGGA EGVKAKYKRD QLPKRRQFTL LVPPPALPAG
DVDIGISTAI ETHVFTEIGK LSGDRVDDKK YPSDRVITTP SLPTVLAKIQ SVRLLSGYSD
IYSSVGNTPT QTSNASSCPT ASFASRVPVR RGGSAPGRSR KATGFVNPLP LLSQSQSRLQ
CRSPSAASSR TATQSRLDTL RGAAETHPPI RPKSVSDLLG LNLDAKSLQG GTPLIERELN
LEVKGKSKST GCWWLDVSCP TWEDLREIGE LLGLHPLTLE DVLQQDPREK LDRFDKLGYY
FLVVRALDEN YFKYTPGSSV PSPSTPSRER NGKGGNAQTA ESISTEKELI DEKDGLGQGA
DGRYRGNRNE DGSDQRQDVE GLEYKKSERR RRGWGMGRAQ GKMAGKMGEK VEIIEDRPGE
EGLEGVGVGA VNVYLVVFAD GIISFHFEDI SKHTNRVLDR VLTLANPDHG ADWIAHGLLD
SIVDAFFPII RYVDGAVDDI DSLTIDPTTD PKKTTAYLGL GLGSVTVGIN EDGSENFKQD
EMGSAKKRNG LWRTPDHLST PHISLCKRLR ASFPHFYPPP QLLRPFTYLR LFLLPTSSAV
KRKHEQAPKM VFDRSTMLKN MTDMRKLVTG LTRLLIAKGA VIGRLRKRAK EEGGTVEAYI
GDVEDHILLL QNSLYHYEYI LSHCQPAYLS HLNVSFAFTK GRTDQAILAL SVIAISILPM
QFITSLFSMN VNVPHNGWKQ CPTHNLCEPD GSLAPFNYFA AIVTGIALVA CCMVSIIRWW
RWNARKKFGR LRGVEVPSAW DGFWGWE
//
