ID E6QZS4_CRYGW Unreviewed; 1114 AA.
AC E6QZS4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 08-NOV-2023, entry version 64.
DE SubName: Full=Translation elongation factor 2, putative {ECO:0000313|EMBL:ADV20068.1};
GN OrderedLocusNames=CGB_B0360W {ECO:0000313|EMBL:ADV20068.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV20068.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV20068.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
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DR EMBL; CP000287; ADV20068.1; -; Genomic_DNA.
DR RefSeq; XP_003191855.1; XM_003191807.1.
DR AlphaFoldDB; E6QZS4; -.
DR GeneID; 10186862; -.
DR KEGG; cgi:CGB_B0360W; -.
DR VEuPathDB; FungiDB:CGB_B0360W; -.
DR eggNOG; KOG0467; Eukaryota.
DR HOGENOM; CLU_002794_3_1_1; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000007805; Chromosome B.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16268; EF2_II; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF3; ELONGATION FACTOR-LIKE GTPASE 1; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:ADV20068.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:ADV20068.1}.
FT DOMAIN 10..268
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 203..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 123311 MW; 6F1F636CA0EEACDD CRC64;
MSNTFAVPLQ NTRNVTIVAH VDHGKTSFAD SLLSSNNIIS SRMAGKLRFL DSREDEQERG
ITMESSAVSL RFDMTRLSPD GTSGIQQCIC NVVDTPGHVD FASEVSTASR LCDGALVLVD
VWEGVATQTI AVLRQAWMDK LKPLLVINKM DRLITELKLS PSEAYHHISQ LIEQVNAVMG
SFYASERMED DLRWREEREK RLTARKEQQG EDPDDEEEYE EKEDEDIYFA PDRGNVLFAS
AIDGWAFRLG KFARLYAEKL KIKEGNLRRV LWGDWYLDPK TKRVVGRKKL AGRNLKPMFV
QFVLENIWRV YDTVLNEHNP DAVQKIVTAL NVRITPRDIR SKDTRNLLNL IMQQWLPLST
ATFQSIIEVI PPPPSAQAIR LPYMLHTEKA KAAAASGGLK AENELERGLY ECDQGEGAEV
VAYVSKMFAV RKRDLPEYKP KEITAEEMRA RGREERERRA ALVAERQAKG ESLDGQPLPE
DLAKPLESLS LESSQPSASK GPAIDDSDSE VLLGFSRIFS STLHRGTSLL AILPKFDPSL
PASHPHNAKH IVPIIASDLY MMMGRELVSV DNVPAGHVCA IGGLDKAVPR SATLWAPDAK
GVEEGSGREV LVNLAGAGIG ASAIVRVALE PENPSDMPKL IRGLQILNQA DPCAEYLVQE
TGEHVIITAG ELHLERCLKD LRERFAKCPI QQSAPIVPFR ETAVKAPDMV PPKTVGAPRG
TVNGTVLNGL VKFRLRAMPL PKGVETLLLS QQGAISKMLV RERGRKEGEE ETDVQEGAER
QSADGEGLES QQEARQLSPE EFWTELERLL NKAGGDWTGA ADRVWSFGPK RVGANLLLDP
VGTKHLRLRG REQLFNQARA QGQSADDALL ATDDAVAADQ LASLNSTTSD NEAARADLRL
LRDYESSIEA GFQLSTFQGP LCAEPVVGMA WVVESVELDK EGLESEQGKG QVVGGALISA
VRDACRQGLL DWSPRIKLAM YTCDIQASTD VLGKVYGVIA RRRGRIVSEE MKEGTSFFTI
RSMLPVVESF GFADEIRTRT SGAASPQLIF SGYETLDLDP FWVPTTQEEL EDLGEKADKA
NVAKAYVDGV RKRKGMFVER KIVEFAEKQR TLKK
//
