ID E6R1J5_CRYGW Unreviewed; 646 AA.
AC E6R1J5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Transketolase, putative {ECO:0000313|EMBL:ADV20663.1};
GN OrderedLocusNames=CGB_B9700C {ECO:0000313|EMBL:ADV20663.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV20663.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV20663.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; CP000287; ADV20663.1; -; Genomic_DNA.
DR RefSeq; XP_003192450.1; XM_003192402.1.
DR AlphaFoldDB; E6R1J5; -.
DR GeneID; 10188119; -.
DR KEGG; cgi:CGB_B9700C; -.
DR VEuPathDB; FungiDB:CGB_B9700C; -.
DR eggNOG; KOG0523; Eukaryota.
DR HOGENOM; CLU_028734_0_0_1; -.
DR OrthoDB; 1691772at2759; -.
DR Proteomes; UP000007805; Chromosome B.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43825; PYRUVATE DEHYDROGENASE E1 COMPONENT; 1.
DR PANTHER; PTHR43825:SF1; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 66..264
FT /note="Transketolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00456"
FT DOMAIN 335..438
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|Pfam:PF02779"
FT DOMAIN 519..603
FT /note="Transketolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02780"
SQ SEQUENCE 646 AA; 70964 MW; D937A2F15525CD9E CRC64;
MSVNKVQDWD FEKFPIDLKK YKPFPLDPTK DKKLSQEQKD GLIANISLLR DVIVFFTATG
AARGLAGHTG GAFDTIPEVV ILLSFLLADK DKSKYVDTLF DEAGHRVATQ YLLSVLDGYI
PVEHLLHYRE ANSKLPGHPE LGLTPGVKFS SGRLGHMWPL VNGVALAQRD KTVFMLGSDG
SQQEGDDAEA ARLAVAQNLN VKLFVDDNDV TIAGHPSEYL KGYSVAKTLE GHGLKVVEAN
GEDLDSLYSA IVEVVSHKGP AAVVTHRPMA PKIKGIEGSP HAHDAIKVEP AIEYLDARHP
KCAAILRAIQ PSTYAELLSG STKERGACRV QFGEAVSAVL DKTSKEQNKA KVLVIDTDLE
GSTGLSVIHK KHPEVFLSSG IMERGNFSAA AGWGAFNADR QGVFSTFSAF SEMIISELTM
ARLNFANVLT HFSHSGVDEM ADNTCHFGIN QFFLDNGLED GYETRLYFPA DCSQMDAIID
RVFYDKGLRF VFSTRSKVPW ILKEDGSRFF DADYKFVPGK DEVIRKGTKG YVVAYGEILY
RALDAVDRLR KEGLDVGLIN KSTLNVVDED MIKEIGSTEF VFVAESLNRK TGLGSKFGTW
LLERDLKPRY DYIGTSKEGC GGLGEQIGHQ NLGSSDIALK VKQLIK
//
