ID E6R749_CRYGW Unreviewed; 1079 AA.
AC E6R749;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 22-FEB-2023, entry version 62.
DE SubName: Full=Endocytosis protein end4, putative {ECO:0000313|EMBL:ADV22756.1};
GN OrderedLocusNames=CGB_E4030C {ECO:0000313|EMBL:ADV22756.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22756.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV22756.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR EMBL; CP000290; ADV22756.1; -; Genomic_DNA.
DR RefSeq; XP_003194543.1; XM_003194495.1.
DR AlphaFoldDB; E6R749; -.
DR GeneID; 10189809; -.
DR KEGG; cgi:CGB_E4030C; -.
DR VEuPathDB; FungiDB:CGB_E4030C; -.
DR eggNOG; KOG0980; Eukaryota.
DR HOGENOM; CLU_004601_0_0_1; -.
DR OrthoDB; 7775at2759; -.
DR Proteomes; UP000007805; Chromosome E.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR CDD; cd17007; ANTH_N_Sla2p; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 31..159
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 834..1077
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 420..531
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 579..638
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 302..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 122396 MW; FC07996515D20693 CRC64;
MFGRHNADYD DYPSVRAAAS GSSHQPTRPV DKEKTEAELS VNIKKATSPE ETAPKQKHVR
KCIVYTWDYH SSLSVWNGLR TQPILADEVQ TFKALIVVHK LLQEGHPVTL KEAHAQTGWL
ETCGRTVGDS GKGYGALIKA YTSFLLAKLR FHRHHPEFNG LFEYEEYISL KNIDDPNEGY
ETITDLMTLQ DQIESFQKLI FAHFRGSANN ECRISALVPL VKESFGIYKF ITSMLRAMHR
RTDAADALLP LRERYNAQHY NLRRFYYECS NLKYLTGLIN VPKLGQEPPN LIDNGVAPEL
PERPTTDKRP ERKETPRPSS PQATQGEIDE QRRMLEEYER KQSALVAQRE ADQRRQEEEK
RHQEAQYAEQ QRLQQEREAQ AQHQLQEQLL RDQMSQQWTQ QQAGQAAQLQ QEMLAMRGQY
ERDQMLLEQY DRRVKALEQE LGSIGVNIGA QMSAKDELIA HLQQQIETWK NKYEALAKLY
SQLRTEHLDL LSKTKGFQLK ANSAQEAIDK MERMERDVKA KNLELADMIR ERDRARYDLD
RLKSSHREET DRIKRDLAFA NERAEDASRH KSSEVSDVMS RYNRQLTELE DSLRAKQLQI
DDLLRKLDEK QAEVQHVMDE KEQELAIMQE GMDSTLKQLG DLKLTQGETN QALDAQIDTL
ILDHRKELNV IIDSILQACM QKVDDAIYEL EAPMQTGNTT ATPEYTLSMI EKAMTNATEF
ASTFNLYLSK KSGGGQVDVI KTANEFCQAL CETLVSSKGI TRFAETDDSS EKLVRIAKDA
GDAGYRFFLN LQSFRLLAGG KNEEAALRNN AETRSALSKL SDTVEKFVPK AKTTLAQANG
DIGDIVSQEM QNAAKAIEEA TQRIQVLMSR PKNISKYDSL DIQVHDAILQ ATLAITNAIG
RLIKAATDSQ EEIVREGKGT STTQQFYKRN NRWTEGLISA AKAVAYATGL LIESADGVIS
GTHSLEQLIV ASNEVSAATA QLVAASRVKA SLMSKSQQLL ELAAKAVTDA CKALVKQVKL
ISNKQSDDEV VDYKSMPSHE FKVREMEQQV EILKLEKELG AARRRLGEMR RAGYHQETD
//