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Database: UniProt
Entry: E6R831_CRYGW
LinkDB: E6R831_CRYGW
Original site: E6R831_CRYGW 
ID   E6R831_CRYGW            Unreviewed;       142 AA.
AC   E6R831;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Sorting nexin-3 {ECO:0000256|ARBA:ARBA00020436};
GN   OrderedLocusNames=CGB_F3140W {ECO:0000313|EMBL:ADV22948.1};
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22948.1, ECO:0000313|Proteomes:UP000007805};
RN   [1] {ECO:0000313|EMBL:ADV22948.1, ECO:0000313|Proteomes:UP000007805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WM276;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 0:0-0(2011).
CC   -!- FUNCTION: Required for retention of late Golgi membrane proteins.
CC       Component of the retrieval machinery that functions by direct
CC       interaction with the cytosolic tails of certain TGN membrane proteins
CC       during the sorting/budding process at the prevacuolar compartment.
CC       Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).
CC       {ECO:0000256|ARBA:ARBA00025533}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC       apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004255}. Prevacuolar compartment membrane
CC       {ECO:0000256|ARBA:ARBA00004179}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004179}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004179}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; CP000291; ADV22948.1; -; Genomic_DNA.
DR   RefSeq; XP_003194735.1; XM_003194687.1.
DR   AlphaFoldDB; E6R831; -.
DR   GeneID; 10190305; -.
DR   KEGG; cgi:CGB_F3140W; -.
DR   VEuPathDB; FungiDB:CGB_F3140W; -.
DR   eggNOG; KOG2527; Eukaryota.
DR   HOGENOM; CLU_057172_2_2_1; -.
DR   OrthoDB; 5475877at2759; -.
DR   Proteomes; UP000007805; Chromosome F.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd07295; PX_Grd19; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR042138; PX_Grd19_PX.
DR   PANTHER; PTHR45963; RE52028P; 1.
DR   PANTHER; PTHR45963:SF2; RE52028P; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121}.
FT   DOMAIN          20..137
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   142 AA;  16639 MW;  DB8413335462A835 CRC64;
     MARMAGRPQT FDEMYSVPES FLEIEIRNPM THGIGRKMYT DYEIVCMTNI PAFKLRHSAV
     RRRYSDFEAF RDILERESTR VNIPPLPGKV FTNRFSDEVI EQRREGLQRF LEIVAGHPLL
     QTGSKVLCAF LQDPAWDKSQ WI
//
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