ID E6R8Z5_CRYGW Unreviewed; 833 AA.
AC E6R8Z5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=DNA repair metallo-beta-lactamase domain-containing protein {ECO:0000259|Pfam:PF07522};
GN OrderedLocusNames=CGB_G0680W {ECO:0000313|EMBL:ADV23703.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV23703.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV23703.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR EMBL; CP000292; ADV23703.1; -; Genomic_DNA.
DR RefSeq; XP_003195490.1; XM_003195442.1.
DR AlphaFoldDB; E6R8Z5; -.
DR GeneID; 10190803; -.
DR KEGG; cgi:CGB_G0680W; -.
DR VEuPathDB; FungiDB:CGB_G0680W; -.
DR eggNOG; KOG1361; Eukaryota.
DR HOGENOM; CLU_005260_4_1_1; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000007805; Chromosome G.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 666..794
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 32..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 92193 MW; E1DDA74164BEC7E4 CRC64;
MAPATTTIKK PLPPPSERGT LLSFFKKETT SVETGFHASQ TRIKKEVVSI EPTAGPTKPS
QTRNNSSEQS SIRRGKGKEG QQDHNGSAHD PVVISDDDED DLLPPTPPSS SKRRKVSIPS
SNQSQAPQRS SRQSPNRLFK APTIFAGCPD FNPPPKWPHI VNTADVEEDD DDEIMLVSDE
DATRTQDPGE GEIEEDDPGV EMGDNDRRRT PEVQATQSGE NLPAGGMEWE EPDEGMGMED
EVDDADDAQS AVSSSIKSLT SKSSSRTISS FSFSIVPPEP PPQSAIKGPN AFSLLMSGHK
EHEQWKDVEA DLRRDGKRFA GRRRAPFYKV LTGMPVAVDA FRYGAIPGVT AYLLTYVISI
NFTLLSQLTE KNRHAHSDHY TNLSKSWNNG PIYCSETTAN LIIHMLEVDP KWVHGLPNDV
PFEMPNTGGV TVTPIEANHC PGSSIFLFEG RQTVNAGDSG FASPYVGSKR VFRYLHCGDF
RANPQMVLHP AIARAPINTC YLDTTYLNPK YCFPPQPLVI NACATLARRH VVGGSEDAPS
LEAVQQGSVI GVSGVASTTH SGGRKVTLKT EDGGEREIEV EVKEEKGEKE KQMMQGWLVK
KKDRVKEEVK EESGQVGKKA KSRTLVVVGT YSIGKERIVK AIAKAIGSKI YCDQRKKGIL
LCQTDPELHS MLTSDPIEAQ VHLLPLGNIQ LDRLQSYLTL LYPHFDRVLG FRPTGWSYSP
PAGTDMLPDV NTVIRRDQAR RFGEGDLKTM RGSSRNFMMY GVPYSEHSSF FELTCFALSL
PGADLKMIAT VNVGNEKNRA KMKKWFEKWL AEKARRKEKG LPSTVEYRDE TFW
//
