ID E6RDJ2_CRYGW Unreviewed; 1167 AA.
AC E6RDJ2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Exocyst protein, putative {ECO:0000313|EMBL:ADV24943.1};
GN OrderedLocusNames=CGB_K2170C {ECO:0000313|EMBL:ADV24943.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24943.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV24943.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SIMILARITY: Belongs to the SEC3 family.
CC {ECO:0000256|ARBA:ARBA00006518}.
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DR EMBL; CP000296; ADV24943.1; -; Genomic_DNA.
DR RefSeq; XP_003196730.1; XM_003196682.1.
DR AlphaFoldDB; E6RDJ2; -.
DR GeneID; 10185264; -.
DR KEGG; cgi:CGB_K2170C; -.
DR VEuPathDB; FungiDB:CGB_K2170C; -.
DR eggNOG; KOG2148; Eukaryota.
DR HOGENOM; CLU_002075_0_0_1; -.
DR OrthoDB; 1547052at2759; -.
DR Proteomes; UP000007805; Chromosome K.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd13315; PH_Sec3; 1.
DR Gene3D; 2.30.29.90; -; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR048628; Sec3_C.
DR InterPro; IPR019160; Sec3_CC.
DR PANTHER; PTHR16092:SF14; EXOCYST COMPLEX COMPONENT 1 ISOFORM X1; 1.
DR PANTHER; PTHR16092; SEC3/SYNTAXIN-RELATED; 1.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF20654; Sec3_C-term; 1.
DR Pfam; PF09763; Sec3_CC; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 48..133
FT /note="Exocyst complex component Sec3 PIP2-binding N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01313"
FT REGION 141..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 129344 MW; 231C3FA69A52C16A CRC64;
MSSVPRISPQ DDVRAHITAS LCAQRAPDGT PEETLITFLK VYEEDPAGGT KSRYLILAVQ
RTGRVFIHKA KRNSNLSFSK GKTWYLEDVR VLEVMGPSDF ALTMTTRRYH WTTERPKDQA
AFLTSVVKVY KEYTHGRLPE LINFAPPSSQ PRPPSQQQVP PDTDLNEPFP LPRVGNTDLT
PPQPFGRSYR ANSSSSVNSS QTLGSHYQPS YSESSRGRPS QDDDHTARRP STGDGRAAMP
PRAVGPGNGV GMGPPPAQRK MSDDKAERIG PSALRNVSAA SEYEPGAAGD ASLRMKKSES
DMGAIAETET ERSVSAGDGG KANQSNRIPS APVIREPSPP QQSTSTPQAS EKVKPKPAPP
TITTTDLSVP SPGLTTSATF SSSPVSATRP SRRASFHPPP LDTTISRDVL LQSRTGLLPG
AAGMTIDASE GDDGVLKNVE EMLEGFDWGM IAGGLGVSGE GRKKGADVIE NRLLDELTAL
DSAIIHAFLE SDDRTAQVLA HIDEALMELD DIDLQTTGYR MQLNAVSDDI SYIESQGKGL
QVQTSNQQVL LNELRQLLQI VEVPADDLHT LIKEPPSSEQ GVKALERAAA SLYKALQAGM
DTANAEVAAT IARMQEYREQ SSKFCKRMSD YLDITFQYQA DSTLADFRKN FKKTMALESH
QKMCEKLMIY TGLVLYIKEM DDARYQKLCS DYMSRVSQLH QSEMRELLTY LASLNVSFGD
AGADAAFSSA PGANYAKPSA LQKSKTAIGF GLGNQPKQEK RTDNNTGRAA ELYRQAFTQI
IRQIVVEENF INAFLRPVDT ESTFADYMEL DSYFRRQAAR HASRARSAGM IQLLRSMMDL
IFGFVEVELK NWVEATVEKV PVAIVGIIAV TERLAKEAEE ENTSIFFAQL FDKQLLKQRL
VMDMFVNKQV KSIEAAKTII RRRKGIAFFV KHFPIFVERV EQQMDGNGDL PIRIKVNEAY
ERVITSVFGS LEQLAKMERA ETQANEDKGQ LNYHVIMIEN LHYFIEDVSQ IKSTAMAGFL
QRAKSLYEEN MSMYIKLMLR RTFARFIDFF DGVDRLLQST PANEVSLHHS YSRSALKKVL
KDHGAKDMRK AVETMSRRVD KHFADDEEPS TSTANMALIG MVWKELTQQF AKETLRAQGI
VAKSYGDSGL GLEFSAADVE ATCKKMK
//
