ID E6REW8_CRYGW Unreviewed; 1289 AA.
AC E6REW8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Pre-rRNA-processing protein fhl1 {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CGB_L2230C {ECO:0000313|EMBL:ADV25295.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV25295.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV25295.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; CP000297; ADV25295.1; -; Genomic_DNA.
DR RefSeq; XP_003197082.1; XM_003197034.1.
DR GeneID; 10185560; -.
DR KEGG; cgi:CGB_L2230C; -.
DR VEuPathDB; FungiDB:CGB_L2230C; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_262723_0_0_1; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000007805; Chromosome L.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00059; FH_FOX; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF343; FORK HEAD DOMAIN TRANSCRIPTION FACTOR SLP1-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
FT DOMAIN 158..205
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 738..835
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 738..835
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 57..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..362
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..596
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..631
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..670
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1089
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1289 AA; 136368 MW; F9BD64608DA8D7E2 CRC64;
MSHHPPAPSL AALPVDTSKT DPTPAYYKLQ FGDDLTGFSY YVRTLTVVIG RNCERPAPVP
PPAITNPSVP TNPPLDPNEP SPPSLYSGSI LRTPPVANFN SPSVVEEDHE VNLEDYGPLV
ELAEAVAVKE EDVADNISPV LELPDAPPPP PPPKSSANIE HVDVDLGPLK SVSRNHAKIE
YRSDLGRFCL EILGRNGAWI DDRYYVKGAV VPLAQGAQIQ IATRIFSFVL PPSSVSSPPY
NYYDQSTLEN VENLPYPYNL PASEVRYQEF FGEAGPGPAT AAAMASRQPP AFNAFAAADG
YGLGLGVDVE GQWGQWESEE ESDSDAERDY EQSFERDSER DAHDEDQAED EDWDDAQSDE
EDEYEEVKPK QATKIKLKKP LIVPGEDESD LSSLDSEPER PLKSVKKQAG KKQSQSQSKS
AENEKAKAPK DAKKLSKKES KSKKKVKEPS PPVEEAPGEV KGTPSKSKKK EKEKEKNKAD
SGAEQKQDIS AVTSDEKEKA TPQKKDQKKK IKPASESKPP AKPAPGLKLP IPLAQQQQQQ
QQPSAAQPQP PSVPTLAAAL ANTPTPPTTA PTPAPQPAVR PPQQPVRPPQ QPVRPAPGQP
QQAAVRHPGV PGQPGQPMIR PGQPGVPMGV RPPMSGPGQI PVRPGQPHPH LKQPLPSTPG
VRPPLPQTSV PRTTPSSAGT TPQPTQPFFC TELKETAGRP GHIIVNVPIP PSGAGPRPPP
GPILGLDGKP FVGPPPLKPT STFATIIHKA LSCLPRGRGT LGEVCNWVAG EWEWFRLNVD
SGWQNSIRHN LSLNKAFLKV PRIPEDDPES KGSVWIIDPQ EGPLFEEKQR RDAMKSASKD
KNAESRREKE RIRAEERAKK QREAAIEAAR NPHAHPSYVH HPHPTMARAM PPMATARAIA
RPPANVAHPH PQPSATQPTP SQPTSANIKG VLQPKAKITV VMQPITPALR AKSVIANTDS
NGNPLPFVCD GTTLVLDQST FGHLTSDILD KLTLLGAAGA VDVLSAWVIN KNKMQASKAA
QQAKTGATGT TTTSSAAPGV AGAKNGVVNG AVRPTNGVQP ARPQPHVPPK PNTIPPVRPV
VPPKPAATPT APTVTATTAS ANPTPATTPA VKPASSSTPK SLPGPAPPGT SLTKVIGMIA
AVANAKGDVN TVGPNASALL RYIRVVGVEI DLRVAERIWA TGVVPPLPVK KVAKPANGAA
TGSAVAGGAK PTQGAGVKPQ GQAQGGVKPV QSTSVPASAS NASVVAGMKR KLEDGAQGQG
QSQGNSNGAA SGTGVDQEAK KPRLETSSV
//
