ID E6RFK2_CRYGW Unreviewed; 441 AA.
AC E6RFK2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Iron transporter, putative {ECO:0000313|EMBL:ADV25588.1};
GN OrderedLocusNames=CGB_M3490W {ECO:0000313|EMBL:ADV25588.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV25588.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV25588.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000256|ARBA:ARBA00008333}.
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DR EMBL; CP000298; ADV25588.1; -; Genomic_DNA.
DR RefSeq; XP_003197375.1; XM_003197327.1.
DR AlphaFoldDB; E6RFK2; -.
DR GeneID; 10186323; -.
DR KEGG; cgi:CGB_M3490W; -.
DR VEuPathDB; FungiDB:CGB_M3490W; -.
DR eggNOG; ENOG502QQWE; Eukaryota.
DR HOGENOM; CLU_046738_1_1_1; -.
DR OrthoDB; 1386471at2759; -.
DR Proteomes; UP000007805; Chromosome M.
DR GO; GO:0033573; C:high-affinity iron permease complex; IEA:InterPro.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR PANTHER; PTHR31632; IRON TRANSPORTER FTH1; 1.
DR PANTHER; PTHR31632:SF2; PLASMA MEMBRANE IRON PERMEASE; 1.
DR Pfam; PF03239; FTR1; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW Iron {ECO:0000256|ARBA:ARBA00022496};
KW Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022496}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 385..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 48730 MW; 77ABE6C5124FA6E3 CRC64;
MAKDVFSVPI FFIVFRETIE AAIIVSVLLS FVEQLMLTSR PTQDESDLNI ENSSNNELRV
DAEDSGNVET DKERRAKLVR RMRIQIWAGT GAGFFISLCI GAAFIAVFYT TLTDLWANTE
QLWEGVFSVI AAGIIYVMAT AFLKMDRSRI KWRLKLAAAF DQSQAKMLAL EKMSEHERKL
AKQEGRSGKW ALFLLPFITL LREGLEAVVF VGGVSLGLPA TSIPLAVVVG LIAGFAVGYL
IYRTGSTTTL HWFLVGSTSF LCLIGAGLLS KGVGFFQYYH FSKGVGGDVA ETGDGPGSFQ
VAGNVWHLEY GNPEPGSATT NGGWQIFNAI FGWNNTATLG TILSYVFYWI LVAATLVYLK
WKEGRTSFFG YKSAALQRRH ALREARKANE VARQNTEQYQ TDEKAYNGNQ GSVDGERSNE
GKSPVVTPAD ERNVPALERH Y
//
