ID E6S721_INTC7 Unreviewed; 248 AA.
AC E6S721;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Thiamine monophosphate synthase {ECO:0000313|EMBL:ADU47916.1};
GN OrderedLocusNames=Intca_1400 {ECO:0000313|EMBL:ADU47916.1};
OS Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 / NBRC
OS 12989 / 7 KIP).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Intrasporangium.
OX NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU47916.1, ECO:0000313|Proteomes:UP000008914};
RN [1] {ECO:0000313|EMBL:ADU47916.1, ECO:0000313|Proteomes:UP000008914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC {ECO:0000313|Proteomes:UP000008914};
RX PubMed=21304734; DOI=10.4056/sigs.1263355;
RA Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S., Cheng J.F.,
RA Detter C., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Ivanova N., Mavromatis K., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Pukall R., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Intrasporangium calvum type strain (7 KIP).";
RL Stand. Genomic Sci. 3:294-303(2010).
CC -!- FUNCTION: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole
CC monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine
CC pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
CC {ECO:0000256|ARBA:ARBA00003814}.
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; CP002343; ADU47916.1; -; Genomic_DNA.
DR AlphaFoldDB; E6S721; -.
DR STRING; 710696.Intca_1400; -.
DR KEGG; ica:Intca_1400; -.
DR eggNOG; COG0352; Bacteria.
DR HOGENOM; CLU_018272_3_4_11; -.
DR Proteomes; UP000008914; Chromosome.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00564; TMP_TenI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR036206; ThiamineP_synth_sf.
DR InterPro; IPR022998; ThiamineP_synth_TenI.
DR PANTHER; PTHR20857:SF15; THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME; 1.
DR PANTHER; PTHR20857; THIAMINE-PHOSPHATE PYROPHOSPHORYLASE; 1.
DR Pfam; PF02581; TMP-TENI; 2.
DR SUPFAM; SSF51391; Thiamin phosphate synthase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008914};
KW Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977}.
FT DOMAIN 13..74
FT /note="Thiamine phosphate synthase/TenI"
FT /evidence="ECO:0000259|Pfam:PF02581"
FT DOMAIN 114..223
FT /note="Thiamine phosphate synthase/TenI"
FT /evidence="ECO:0000259|Pfam:PF02581"
SQ SEQUENCE 248 AA; 25710 MW; 878A361534EDBCB3 CRC64;
MVSLREAAGL AIAVTDRSQV PGNRPLLDVV RAVLEGGAHG VLVRERDLAD EERAALVTGV
GPLCAEHQAL LLVASPLPHP HLPHPHLPPP QGRCDRSRSA SVDHIESGEG RRLGLHLRRH
EGVPADLDRV ATFVGRSCHD LAELRRAADD GLDHVTLSPV AASVSKPGHG PALGPAGLRR
LASTVRREHP TPPVIFALGG VDAANAGHWI AAGADGVAVM GAVMRAADPT AAMRAVVDSV
RAARAGAS
//
