ID E6SRK9_BACT6 Unreviewed; 591 AA.
AC E6SRK9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Signal peptide peptidase A {ECO:0000313|EMBL:ADV45099.1};
GN OrderedLocusNames=Bache_3174 {ECO:0000313|EMBL:ADV45099.1};
OS Bacteroides helcogenes (strain ATCC 35417 / DSM 20613 / JCM 6297 / CCUG
OS 15421 / P 36-108).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=693979 {ECO:0000313|EMBL:ADV45099.1, ECO:0000313|Proteomes:UP000008630};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P 36-108;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Ivanova N., Zeytun A., Brettin T., Detter J.C.,
RA Tapia R., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Bacteroides helcogenes P 36-108.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV45099.1, ECO:0000313|Proteomes:UP000008630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35417 / DSM 20613 / JCM 6297 / CCUG 15421 / P 36-108
RC {ECO:0000313|Proteomes:UP000008630};
RX PubMed=21475586; DOI=10.4056/sigs.1513795;
RA Pati A., Gronow S., Zeytun A., Lapidus A., Nolan M., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Liolios K., Pagani I., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C., Brambilla E.,
RA Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Lucas S.;
RT "Complete genome sequence of Bacteroides helcogenes type strain (P 36-
RT 108).";
RL Stand. Genomic Sci. 4:45-53(2011).
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; CP002352; ADV45099.1; -; Genomic_DNA.
DR RefSeq; WP_013548686.1; NC_014933.1.
DR AlphaFoldDB; E6SRK9; -.
DR STRING; 693979.Bache_3174; -.
DR KEGG; bhl:Bache_3174; -.
DR PATRIC; fig|693979.3.peg.3326; -.
DR eggNOG; COG0616; Bacteria.
DR HOGENOM; CLU_008856_1_1_10; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000008630; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008630};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..277
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 375..519
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 191
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 391
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 591 AA; 65250 MW; 515E0835F9AB7439 CRC64;
MKDFLKFTLA TITGIIVSSI ILFFISILVF FSIVSSSDSE TQVRKNSIMM LDLNGMLAER
TQENPFDFLL GDEYNTYGLD DILSSIKKAK ENADIKGIYI QACSLGGASF ASLEEIRNSL
KDFKESGKFI VAYGDTYTQS LYYLSSIADK VLLNPKGAVE WKGLAASPMF FKDLLGKIGV
EMQIFKVGTY KSAVEPFIST EMSPANREQV NAYLASIWKQ IMGDVATSRK ISVDSLNAAA
NSMLMFYPAE RCVKAGLADT LIYKNDVRNY LKTMAGIEEN DKMPVLSLKN MVNIKKNVPK
DKSGNVIAIY YAYGEIDGGS SSTLTGEEGI NSEKVIKDLR KLKDDKDVKA VVLRVNSPGG
SAYGSEQIWY AVSELKKKKP VIVSMGDYAA SGGYYISCNA DTIVAEPTTL TGSIGIFGMF
PNAKGLADKI GISFDVVKTN RYSDFGMITR PMNEGEKGLL QMYINQGYDT FLARCSEGRG
ISKEELDKIA QGRVWTGSKA KELGLVDELG GIDRALEIAI AKAGTDTYTI MSYPKKENFL
ESFMNSNPGN YIKAHLLNSK VGEMYKQFSI LDNFDRCDRL QARVPFELNI Q
//
