ID E6U460_ETHHY Unreviewed; 1128 AA.
AC E6U460;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ADU26560.1};
GN OrderedLocusNames=Ethha_1007 {ECO:0000313|EMBL:ADU26560.1};
OS Ethanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 /
OS YUAN-3).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ethanoligenens.
OX NCBI_TaxID=663278 {ECO:0000313|EMBL:ADU26560.1, ECO:0000313|Proteomes:UP000001551};
RN [1] {ECO:0000313|EMBL:ADU26560.1, ECO:0000313|Proteomes:UP000001551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3
RC {ECO:0000313|Proteomes:UP000001551};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Wang A.,
RA Mouttaki H., He Z., Zhou J., Hemme C.L., Woyke T.;
RT "Complete sequence of Ethanoligenens harbinense YUAN-3.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002400; ADU26560.1; -; Genomic_DNA.
DR AlphaFoldDB; E6U460; -.
DR STRING; 663278.Ethha_1007; -.
DR KEGG; eha:Ethha_1007; -.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG2200; Bacteria.
DR eggNOG; COG2202; Bacteria.
DR HOGENOM; CLU_002248_3_0_9; -.
DR OMA; YTENESY; -.
DR Proteomes; UP000001551; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 2.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 2.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF45; FYVE-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 2.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 2.
DR SMART; SM00086; PAC; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 2.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001551};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..150
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 154..205
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 365..498
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 723..855
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 864..1118
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1128 AA; 129007 MW; 935F1D0DC0CD8FC4 CRC64;
MRCGPQCGGN RVKKKRFLNR HAALFVIYGL LTVESIYRIA IAGGAPGSLW VEFLIGAGIA
GVYFMAVHIY ENWLTHSQFR VLVDRIHCGI AIIRMDEGFS LLRANPAFFR ISGYTPDEFL
EKFDNKAIYM LCMEDHAAVY EEIKKMDTKQ RVHVHVDFRI QSKDGRIKWI HMDSFLFHAE
GREPVFQCIF TDITALRSSV EQAEMEAKRY HIIAQLSDDI LFDYDIASKT MTATQPISDL
YAGKTSISDF YNDIVENLVV HKDDVDALAD FAGEPGGIQE KIRTELRIRS ANNGFAWYRM
EGAVLRDKYA KPLKIVGKFT NIDRQKREKE YLTQKLQRDP MTGVFNKVVT EKLIDRYLHK
ADEDDVSALF VMDLDNFKNI NDALGHLSGD RVLTHVAEGI KQILRSSDIF GRIGGDEFVV
FIKNIRSCTF AAQKARQLCQ IFRSPVLEQE LRYAVSGSVG IAMSPTDGKS YHELFEKADR
ALYVAKGQGK DGFAFYQNNL PGEHGASGCE PCKEDALSSR GPSLSFSGRG GIVEGLLAFM
NEHCLDHNAT EQMLGLVCRY YQVKRGRILE FSESGERIEH VYEWHAPGFA SNPYRLLTHP
PVFWKEYLQQ FDQTAVFQCA SLQKAGITPG GEQDLLSLQH LLFSSGQPFS ILMLDNDVPQ
NQLTFYELNV LEIVHHLLQY HLYLLQNLRV SQELINIDSL TGVHTYEYFH TLLKKALLIS
EDMPYVLISC DINRFSEIND LIGHDQADQV LVTFASVIRR CLQPDEYIGR VSVDIFCILA
HAENKENLTA RMDLWDQAFQ QEVEAFHIPS NVQVAVGIYE INAEADTPSI MFDRANAARK
LAKTAHERMV CFYDEKLHEK ILFEKDMESH MVSSLEKNEF VIYLQPKYGL VDRKIAGAEA
LVRWNHPTRG FLGPNDFIPL FEKNHFILEL DFFVFESVCR MLRRWMDEGR PVVPVAVNFS
RVHLLTNDFV EQLIALVDKY QIPPHYLEIE LTESAYISRF HNALQIAQRL RQHGFLMAMD
DFGAGYSSLN SLKSLPLDIL KLDKNFFQEK EPTPKETIII ENIVRLAKQL NLCVVSEGVE
LEWQAEFLCS VDCDLVQGYL FSRPIPVTTF EKILMEHAQP LLHCPPER
//