ID E6U6Z4_ETHHY Unreviewed; 360 AA.
AC E6U6Z4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:ADU26961.1};
DE EC=1.2.1.11 {ECO:0000313|EMBL:ADU26961.1};
GN OrderedLocusNames=Ethha_1424 {ECO:0000313|EMBL:ADU26961.1};
OS Ethanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC 1.5033 /
OS YUAN-3).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ethanoligenens.
OX NCBI_TaxID=663278 {ECO:0000313|EMBL:ADU26961.1, ECO:0000313|Proteomes:UP000001551};
RN [1] {ECO:0000313|EMBL:ADU26961.1, ECO:0000313|Proteomes:UP000001551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18485 / JCM 12961 / CGMCC 1.5033 / YUAN-3
RC {ECO:0000313|Proteomes:UP000001551};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Wang A.,
RA Mouttaki H., He Z., Zhou J., Hemme C.L., Woyke T.;
RT "Complete sequence of Ethanoligenens harbinense YUAN-3.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002400; ADU26961.1; -; Genomic_DNA.
DR RefSeq; WP_013485316.1; NZ_CP025286.1.
DR AlphaFoldDB; E6U6Z4; -.
DR STRING; 663278.Ethha_1424; -.
DR KEGG; eha:Ethha_1424; -.
DR eggNOG; COG0136; Bacteria.
DR HOGENOM; CLU_049966_1_0_9; -.
DR Proteomes; UP000001551; Chromosome.
DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADU26961.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001551}.
FT DOMAIN 5..138
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 158
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 252
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 360 AA; 39982 MW; 1BED5D4493D464F6 CRC64;
MKQYKVGIIG ATGMVGQRFI TLLEGHPWFT VEVLAASARS KGKAYEEAVA GRWFMKKPIP
ETLKAKTLYD AEADLDTIVS QVDFVFCAVN MKKEEIRALE EKYAKVECPV ISNNSANRFT
PDIPMIVPEI NADHAAVIPF QRKRLGTKRG FIAVKSNCSL QSYVPALHPL RAFGMTRVLA
CTYQAISGAG KTFESWPEIL DNVVPYIGGE EEKSEQEPLK IWGKLQNGAI VPESDGPSIT
TQCLRVPVSD GHMAAVFASF AQKPELKQIL QIWKDFKGRA QELQLPSAPK QFLHYFTEND
RPQTRLDREI ENGMAVSIGR LRPDSQYDIK FVCLSHNTIR GAAGGGILMA ELLCAEGYLD
//
