ID E6UKI7_RUMA7 Unreviewed; 497 AA.
AC E6UKI7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Threonine synthase {ECO:0000313|EMBL:ADU24183.1};
DE EC=4.2.3.1 {ECO:0000313|EMBL:ADU24183.1};
GN OrderedLocusNames=Rumal_3748 {ECO:0000313|EMBL:ADU24183.1};
OS Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 /
OS 7).
OG Plasmid pRUMAL02 {ECO:0000313|EMBL:ADU24183.1,
OG ECO:0000313|Proteomes:UP000006919}.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=697329 {ECO:0000313|EMBL:ADU24183.1, ECO:0000313|Proteomes:UP000006919};
RN [1] {ECO:0000313|Proteomes:UP000006919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7
RC {ECO:0000313|Proteomes:UP000006919};
RC PLASMID=pRUMAL02 {ECO:0000313|Proteomes:UP000006919};
RX PubMed=21914885; DOI=10.1128/JB.05621-11;
RA Suen G., Stevenson D.M., Bruce D.C., Chertkov O., Copeland A., Cheng J.F.,
RA Detter C., Detter J.C., Goodwin L.A., Han C.S., Hauser L.J., Ivanova N.N.,
RA Kyrpides N.C., Land M.L., Lapidus A., Lucas S., Ovchinnikova G.,
RA Pitluck S., Tapia R., Woyke T., Boyum J., Mead D., Weimer P.J.;
RT "Complete genome of the cellulolytic ruminal bacterium Ruminococcus albus
RT 7.";
RL J. Bacteriol. 193:5574-5575(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR EMBL; CP002405; ADU24183.1; -; Genomic_DNA.
DR RefSeq; WP_013483728.1; NZ_JHYT01000055.1.
DR AlphaFoldDB; E6UKI7; -.
DR KEGG; ral:Rumal_3748; -.
DR HOGENOM; CLU_015170_3_1_9; -.
DR OrthoDB; 9763107at2; -.
DR Proteomes; UP000006919; Plasmid pRUMAL02.
DR GO; GO:0004795; F:threonine synthase activity; IEA:UniProtKB-EC.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:ADU24183.1}; Plasmid {ECO:0000313|EMBL:ADU24183.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51}.
FT DOMAIN 3..79
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 105..356
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT MOD_RES 113
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 497 AA; 54623 MW; 325AAE073E2E496D CRC64;
MFYRSTRNSG VNVTSAQAIA QGISEDGGLF VPSEIPSISM DDIKKLGDMT YAERAFFVFS
KFLTDYTEAE IRYCVEGAYN TKNFDTENIA ELAHLFDGTY MLELWHGPTC AFKDMALQIL
PYLLTTATKK INLDKKVVIL VATSGDTGKA ALEGFKDVPG TEILVFYPDN GVSAMQKKQM
TTQEGQNVGV CAIKGNFDDA QNGVKAIFTN KEIGEKLAEN GMMFSSANSI NWGRLAPQII
YYVSSYAQLL KDGEIKEGDK INIVVPTGNF GNILAGYYAK KMGIPVNKLI CASNSNNVLT
DFIKTGVYDR NRQFYATISP SMDILISSNL ERLLYHLCGE DDAQIREWFG KLASEGRYEV
TDAVKAVLAD EFYAGCCDDA KTKATIKEYY DKYSYTCDTH TAVAVSVYEE YVKATGDKTK
TVIASTASPY KFSGSVLSAL GKDTGSDEFT LVEELGEASG MPVPASLASL KNKEIRFSKV
IAKDEMKDFV FKALGVK
//
