ID E6V5T8_VARPE Unreviewed; 2453 AA.
AC E6V5T8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:ADU37079.1};
GN OrderedLocusNames=Varpa_2888 {ECO:0000313|EMBL:ADU37079.1};
OS Variovorax paradoxus (strain EPS).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU37079.1, ECO:0000313|Proteomes:UP000008917};
RN [1] {ECO:0000313|Proteomes:UP000008917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Ovchinnikova G., Orwin P., Han J.-I.G., Woyke T.;
RT "Complete sequence of Variovorax paradoxus EPS.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADU37079.1, ECO:0000313|Proteomes:UP000008917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EPS {ECO:0000313|EMBL:ADU37079.1,
RC ECO:0000313|Proteomes:UP000008917};
RX PubMed=24158554;
RA Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT "Genome of the Root-Associated Plant Growth-Promoting Bacterium Variovorax
RT paradoxus Strain EPS.";
RL Genome Announc. 1:e00843-e00813(2013).
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DR EMBL; CP002417; ADU37079.1; -; Genomic_DNA.
DR RefSeq; WP_013541307.1; NC_014931.1.
DR STRING; 595537.Varpa_2888; -.
DR KEGG; vpe:Varpa_2888; -.
DR eggNOG; COG0001; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_9_0_4; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000008917; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 716..794
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 816..1242
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1757..1832
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 309..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2453 AA; 259303 MW; A2A48334FA471542 CRC64;
MNTRFALPSP AADAAPAPSL DDLFVPRRDA TEERLAATLT LEADFAQRWV AWLDTMGFLP
DTLFDAAWRL LQSRWLGAEP DGTADTWLAQ LDRQRRASPH DSESDNAIRL SLDARPGYSA
RLQLDAAATL IDAAAADRLL AAIADTAADL LARPDAALGS IRTLPDADRR DQLDAWNTPP
GAIDRALTVP AMFSRQAAAT PDAVALVEGD EAMRYGELER RSDRFAQHLR QSGVRPGDNV
GMMFERSMDA IVAMLGSLKA GAAYVPVPAD FPAERVAGML GQAGAVRVVV AEALRHLVPA
EIGAGAVLLP SDPDDATEGN AHRGSANTSP DVPDVPDVPE VPDMPVIDGA SVAYVMYTSG
STGMPKGIEI CHRAILRLVV GVDYAEFAPG RAVLHAAPLA FDASTLEVWG PLLNGGRCVI
HGERVPTGAG LARTIAGHEV HTAWLTAGLF NAVVDGDPQH LAGLKHLFTG GEALSVAHVR
RALDALPGLV LSNGYGPTEC TTFAATHRID PASLANGLRS VPLGRPIKDT VLRVLSPSLA
LLPSGLVGEL CIGGHGLARG YLGQPELTAA RFVPDPFGAP GERLYRTGDL ARWLPDGTIE
FIGRIDGQVK IRGHRIETGE IEAAILAHPA VQSCAVIARP ASDGQLRLVA YLVARSEPLP
WDTLRAHLAA RLPAAMLPSA QVWLAQLPVT PNGKLDRKAL PEPAGERPEL AQPFEEARDA
REAQVCAAFA RALCISKVGR NDNFFDLGGN SLLVLQVLAD LQRDAAPHAP PLSTNLFFRH
PTPAAIAAQL QPAAETKHAP STRPDTRTPR APRGGDEPIA LIATAGRFPG ANDVEQFWDN
LVAGRDSVSF FDDATLDAGV NEALRSDPAY VRARGVIEGI ENFDAAFFGI GPKEATLMDP
QHRVFLEICW ECLERAGYVP DEAPGPVGVY AGTYNATYFQ RHVASRPDLV EAVGEFQVML
ANEKDYITTR VANRLNLRGP AVSVNTACST SLVAVAQAFH ALRTGQCYMA LAGGASVTCP
PRSGYLYNEG SMLSPDGRTR SFDAEAKGTV FSDGAAVVLL KRLSDAQADG DTIYAVLRSA
CVNNDGGAKA SFTAPSVDGQ AAVIRAALAA ADVDAQSIGY VEAHGTATPM GDPIEVEALA
VAYAEHTDAR GYCTLGSLKS NVGHMVTAAG AAGLIKAALS LHHEVMVPTA HFNAPNPAID
FARTPFYVSS QLQPWPRADL PRRAGVSSFG VGGTNAHVVL EEAPARAAAP SAATGIHVLP
LSARSEAALA VATQQLAAHL EAHPGLALAD AAFTLSVGRK AHAFRRAVVA ADAPSAIAAL
RMDDAPWRVS GSLAARAPQP VLMFPGQGAQ YAGMGRALHA SDAVFAAAFY DCLRALEGVT
DFDLRERMFG DDPRALAPTA VTQPALFALE YALARRLLSL GLRPHALIGH SVGEFVAAVI
AGVMRLEDAV RLVARRGALM QAMPAGTMLS VRLGADDLAA RLAAWPSVSL AADNAPNACV
AAGPADAIAQ MQAALEAEGI ACRALQTSHA FHSSMMDGAV APFEALVGEV ALHAPAIPIF
STLTGRLLED PEATSPAYWA RHLRGTVCFS PALQSAAAAA AHPVFVEVGP RNTLATLVRQ
HGAKALAPSS SNAGVTAVPL LHGEPADEAR TLRLAAARLW TCGADIELAR LSARGGARRV
CLPTYPFERK RLWVDIAPPA PATTAPVASA APMLAALVPA LAPALSVPPV SLEPTVTAAV
PSTHPPSPSL PAASRAPSVD MRLRSLFEDI SGIDMADAAG EAMFAELGLD SLTLTQAATQ
IKKTFKVNVS FRQLMENYRS FDALAAFLQQ SLPPEVEATP EPLAAAPVQL PAVQPMVQMV
QMASPLPSPS TGAVNQLIAQ QMELMRQQLA LLSGSTAAVA MSVPSPMPMP MPLPVPVQTA
HAVPAQDASP DATREPVRYD VAKAFGAIAR IHTKPTAEPS ARQKARLAAF VRRYVARTQN
SKRFTEDNRA HMADPRVVNG FRPLTKEITY QIVVERSKGS KLWDIDGNEY VDALNGFGLN
LFGWQPDFVQ EAVRKQLDAG YEIGPQHPLA AEVTRLLCEL TGCERAGLCN TGSEAVMAAL
RIARTVTGRS TVVVFTGSYH GTFDEVLVRA GKGGKGLSAA PGVMSGMFGD VRVLDYGTPE
ALAFIRENAE DLAAVLVEPV QSRRPDFQPR EFVQALREIT TQSGTCLIFD EVITGFRTGL
GGAQELFGVR ADLATYGKVI GGGFPVGVIA GKRPFMDALD GGAWQYGDDS IPGVGVTYFA
GTFVRHPLAL AAAKASLEHL KEAGPALQAA LGASTAAMAG ELTAWCAEVG APIAIRHFAS
LWRVNWLEDH PLQDLLFAMM RSRGVHILDN FPCFLTTAHS QEDIATIQRA FKESVAEMQE
SGFLPRRAPA VHAFDVHKPT EEGSILARDV DGQPFWYVPA APEAIQIPNG RAA
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