ID E6X5E6_CELAD Unreviewed; 995 AA.
AC E6X5E6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Celal_3230 {ECO:0000313|EMBL:ADV50501.1};
OS Cellulophaga algicola (strain DSM 14237 / IC166 / ACAM 630).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Cellulophaga.
OX NCBI_TaxID=688270 {ECO:0000313|EMBL:ADV50501.1, ECO:0000313|Proteomes:UP000008634};
RN [1] {ECO:0000313|EMBL:ADV50501.1, ECO:0000313|Proteomes:UP000008634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14237 / IC166 / ACAM 630
RC {ECO:0000313|Proteomes:UP000008634};
RX PubMed=21475589; DOI=10.4056/sigs.1543845;
RA Abt B., Lu M., Misra M., Han C., Nolan M., Lucas S., Hammon N.,
RA Deshpande S., Cheng J.F., Tapia R., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Mavromatis K., Ovchinikova G., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Brambilla E., Rohde M., Tindall B.J., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Cellulophaga algicola type strain (IC166).";
RL Stand. Genomic Sci. 4:72-80(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP002453; ADV50501.1; -; Genomic_DNA.
DR RefSeq; WP_013551962.1; NC_014934.1.
DR AlphaFoldDB; E6X5E6; -.
DR STRING; 688270.Celal_3230; -.
DR KEGG; cao:Celal_3230; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_1_10; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000008634; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:ADV50501.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADV50501.1}.
FT DOMAIN 3..96
FT /note="PHP"
FT /evidence="ECO:0000259|Pfam:PF02811"
FT DOMAIN 253..488
FT /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT /evidence="ECO:0000259|Pfam:PF07733"
FT DOMAIN 492..662
FT /note="DNA polymerase III alpha subunit finger"
FT /evidence="ECO:0000259|Pfam:PF17657"
FT DOMAIN 734..819
FT /note="DNA polymerase helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF14579"
SQ SEQUENCE 995 AA; 113783 MW; 8CE7E936CB1270C1 CRC64;
MYLNCHSYYS LRFGTFSEIE LLKMGQANHI ATLALTDINN TSACMNFVRK SKEYGIKPII
GIDFRNGAEQ LYVGIAKNNE GFRELNAFLS FHSHKNIKLP PIAPVFEHAY IIYPFENVLQ
LEKINFEAHE YIGISVENLR RLPFSKYKSY TDKLVIQQPV TFRNKRDFNA HRLLRAIANN
TLLSKLQQTE EGRLSEQMLS KEKLLEAFQD FPQLVTNTKT LMAQCNVGFG FGASRVSQNQ
QVFGTSKEED FNYLQQLCED GLPKRYPTRT DAVSKRLAVE LETIKKMDFV SYFLINHDIV
KYANSKGYLH VGRGSGANSI VAYIIGITDV DPIELDLYFE RFINPYRVSP PDFDIDFSWK
DREDVTAYIF RRFKNTALLA TYNTFKYRAV VRELGKVFGL PKEEIDKLCK GHFSENNLDD
MGKLVLKYSA LIKDFPNYLS VHSAGILILD QPIHYYSATD LPPKGFATVQ FDMIIAEDAG
IFKFDILGQR GLAKIKEAIE IIKVNRPEVP EIDITQIETF KNDANINNLL SRGKAIGAYY
VESPAMRGLM CKLKVNDYLG LVAASSVIRP GVSSSGMKNE YIRRHREPER RKEANAILAQ
IMPETYGIMV YQEDVLKVAN QFAGLDLGEA DVLRRGMSGK FRSRAEFTRV EEKFRSNCKA
KGYPDALTTE VWDQIASFAG YAFAKGHSAS YAVESYQSMY LKCYYPLEFM VAVLNNGGGF
YSTEHYIHEA RMWGAQIHAP CINLSDHHNT IKGVAIYLGF GYLKNLENLV VQRFLTERQL
YGAFKSLDDF IDRVIISIEQ LAILIRIGAF KFTGLEKNEL HWQGIFKINA LKKRSGNPSL
FKPKHKQFEL PKLAHSWVEE AYDQIELLGF PLYSYFDLIS EEILSDAKAQ DMQHHHNKEL
LLYGILVNTR FNTTKNNKNM RLSTFVDQEG DYFDVVHFTN VVDKYPIHGM GVYACYGKVT
EEFGHCSIAA IWTKKLAFKT DPRASDIPTF ESLKK
//