ID E6ZJZ8_SPORE Unreviewed; 674 AA.
AC E6ZJZ8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN ORFNames=sr11601 {ECO:0000313|EMBL:CBQ67651.1};
OS Sporisorium reilianum (strain SRZ2) (Maize head smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Sporisorium.
OX NCBI_TaxID=999809 {ECO:0000313|EMBL:CBQ67651.1, ECO:0000313|Proteomes:UP000008867};
RN [1] {ECO:0000313|EMBL:CBQ67651.1, ECO:0000313|Proteomes:UP000008867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRZ2 {ECO:0000313|Proteomes:UP000008867};
RX PubMed=21148393; DOI=10.1126/science.1195330;
RA Schirawski J., Mannhaupt G., Muench K., Brefort T., Schipper K.,
RA Doehlemann G., Di Stasio M., Roessel N., Mendoza-Mendoza A., Pester D.,
RA Mueller O., Winterberg B., Meyer E., Ghareeb H., Wollenberg T.,
RA Muensterkoetter M., Wong P., Walter M., Stukenbrock E., Gueldener U.,
RA Kahmann R.;
RT "Pathogenicity determinants in smut fungi revealed by genome comparison.";
RL Science 330:1546-1548(2010).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR EMBL; FQ311430; CBQ67651.1; -; Genomic_DNA.
DR AlphaFoldDB; E6ZJZ8; -.
DR EnsemblFungi; CBQ67651; CBQ67651; sr11601.
DR VEuPathDB; FungiDB:sr11601; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_408921_0_0_1; -.
DR OrthoDB; 5490442at2759; -.
DR Proteomes; UP000008867; Chromosome 1.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072}.
FT DOMAIN 281..344
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 312..346
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 379..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 532..630
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 75631 MW; D601AE5724C9E1D2 CRC64;
MASTNTRRST LAAIDPNQNN GHISSALPVP SSAVKSVKTL SSGSFQPRAS MIPQQSNAAR
QVSAASANAR EAQHTASQHS GPVHSASQSA RRGDSGMYAG RQSVASAGRQ SVAVAATPNS
RRSMVGRLSI APGNIGNTAG SGVRETRPIK DKHYKTRMGL TVKEHLERTG FTMSGWDANK
GVHEPTQSAF VGMFKHIYAT CIDTNFVMGA DGKKFEDEVL TLMKEIKYPA ADELSKTKLT
AAGSQSHWPY CLAMLEWMVN LGNQAETIGT GPRSRPDEID DLQSLFFPYL WDCYDRFWQN
EDTYPEEHAK LGVRFEDKNA AIERELSELQ QEHRKLEAEL ADYLNNDSPL KIESSENDML
AKDISKFHKY YDEVLVPKLD KTKKAIERLV KEIALTEKEI DDKNRRRLDL QEQVNAQEMS
AEEYERMLAE RNRLSKRLEV LGEQNKKAAG DGWGLEIAIA KKQADTEDRI SKFNPLARSI
SLLPFKLASG SVVEELELTP SNPSTMLQPG VEIKGSFRRQ IEALRSQEAD KYRHASKKRL
TMQEEYEKLQ EALSEQESQL ASDRERCEAL SRQAAEYEKS CKTVQERYKA DEAKLERSTY
ETEASGSVHL QQAESRLTSL QLTAEHKEDE WNQQRSRMDE DMLNFVVLLS KMKGDVTGQL
REIQAAVALK SRDD
//
