ID   E6ZLC8_SPORE            Unreviewed;       588 AA.
AC   E6ZLC8;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=L-ornithine N(5)-monooxygenase {ECO:0000256|ARBA:ARBA00018612};
DE            EC=1.14.13.196 {ECO:0000256|ARBA:ARBA00012881};
DE   AltName: Full=L-ornithine N(5)-oxygenase {ECO:0000256|ARBA:ARBA00030351};
GN   ORFNames=sr11996 {ECO:0000313|EMBL:CBQ68131.1};
OS   Sporisorium reilianum (strain SRZ2) (Maize head smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Sporisorium.
OX   NCBI_TaxID=999809 {ECO:0000313|EMBL:CBQ68131.1, ECO:0000313|Proteomes:UP000008867};
RN   [1] {ECO:0000313|EMBL:CBQ68131.1, ECO:0000313|Proteomes:UP000008867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRZ2 {ECO:0000313|Proteomes:UP000008867};
RX   PubMed=21148393; DOI=10.1126/science.1195330;
RA   Schirawski J., Mannhaupt G., Muench K., Brefort T., Schipper K.,
RA   Doehlemann G., Di Stasio M., Roessel N., Mendoza-Mendoza A., Pester D.,
RA   Mueller O., Winterberg B., Meyer E., Ghareeb H., Wollenberg T.,
RA   Muensterkoetter M., Wong P., Walter M., Stukenbrock E., Gueldener U.,
RA   Kahmann R.;
RT   "Pathogenicity determinants in smut fungi revealed by genome comparison.";
RL   Science 330:1546-1548(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC         NAD(+); Xref=Rhea:RHEA:41512, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:46911, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:78275; EC=1.14.13.196;
CC         Evidence={ECO:0000256|ARBA:ARBA00001398};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine +
CC         NADP(+); Xref=Rhea:RHEA:41508, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:46911, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:78275; EC=1.14.13.196;
CC         Evidence={ECO:0000256|ARBA:ARBA00001847};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC   -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC       oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR   EMBL; FQ311430; CBQ68131.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6ZLC8; -.
DR   EnsemblFungi; CBQ68131; CBQ68131; sr11996.
DR   VEuPathDB; FungiDB:sr11996; -.
DR   eggNOG; KOG1399; Eukaryota.
DR   HOGENOM; CLU_006937_7_0_1; -.
DR   OrthoDB; 49786at2759; -.
DR   Proteomes; UP000008867; Chromosome 1.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR025700; Lys/Orn_oxygenase.
DR   PANTHER; PTHR42877; -; 1.
DR   PANTHER; PTHR42877:SF5; L-ORNITHINE N(5)-OXYGENASE; 1.
DR   Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE   3: Inferred from homology;
KW   Monooxygenase {ECO:0000313|EMBL:CBQ68131.1};
KW   Oxidoreductase {ECO:0000313|EMBL:CBQ68131.1}.
SQ   SEQUENCE   588 AA;  66564 MW;  93CBC19B6428A9AD CRC64;
     MANTLPPLDQ PKLTPEYHDV VIVGAGISGI AMACQLKRKL NIHNIKILER SPDPSGTWTN
     NSYPGCACDV PAPVYSFSFA TKGDWSTFYP QQKELKKYFG TVAAEHGLHK NFHFQTTVQE
     ARYDRETGLW HIWSQDWSKG QSGGEKHHFV CKFFVSAVGG LSQPKPCDIE GHESFAGPIF
     HTAAWDHSVN LHGKDVVLVG NGCSATQCVP YLAQHAKSLT QFVRSKHWIA PHPHQPFDSI
     PGFKWLLKKS VFVRKFQRLL IWLVLESHFI MILQNPLGRL FRWNWRRKCE AHMKKNAPRE
     YWDMLLPRKD ELMVGCKRRI IDDDYLPTLR QPHVSVTDVR LARIEPHHVV LADGRRIKAD
     VIVMANGFEP TAAGAPMTIV GANRTLHEHW AKYGEGGMVA YRSSLNAGFP NMGQINAANT
     GTGNQSLIFA SECTVNFLLE IAKPVLASAK PPQFAIDHMP SPELTNDPKL DLYKIPTFEV
     KLKAELDEQH WIAKAMSKLV FTSGCKSWYI DAKSGRVTSM QPDWQVNYML RAHFPKWDDF
     RYTGLKAGSK VPEGVPWWKV WGDWLGLGHV RYVDPKETPQ INRAAMDA
//