ID E6ZSJ4_SPORE Unreviewed; 570 AA.
AC E6ZSJ4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Related to PUS1-pseudouridine synthase 1 {ECO:0000313|EMBL:CBQ70201.1};
GN ORFNames=sr16406 {ECO:0000313|EMBL:CBQ70201.1};
OS Sporisorium reilianum (strain SRZ2) (Maize head smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Sporisorium.
OX NCBI_TaxID=999809 {ECO:0000313|EMBL:CBQ70201.1, ECO:0000313|Proteomes:UP000008867};
RN [1] {ECO:0000313|EMBL:CBQ70201.1, ECO:0000313|Proteomes:UP000008867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRZ2 {ECO:0000313|Proteomes:UP000008867};
RX PubMed=21148393; DOI=10.1126/science.1195330;
RA Schirawski J., Mannhaupt G., Muench K., Brefort T., Schipper K.,
RA Doehlemann G., Di Stasio M., Roessel N., Mendoza-Mendoza A., Pester D.,
RA Mueller O., Winterberg B., Meyer E., Ghareeb H., Wollenberg T.,
RA Muensterkoetter M., Wong P., Walter M., Stukenbrock E., Gueldener U.,
RA Kahmann R.;
RT "Pathogenicity determinants in smut fungi revealed by genome comparison.";
RL Science 330:1546-1548(2010).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; FQ311440; CBQ70201.1; -; Genomic_DNA.
DR AlphaFoldDB; E6ZSJ4; -.
DR SMR; E6ZSJ4; -.
DR EnsemblFungi; CBQ70201; CBQ70201; sr16406.
DR VEuPathDB; FungiDB:sr16406; -.
DR eggNOG; KOG2553; Eukaryota.
DR HOGENOM; CLU_021971_0_2_1; -.
DR OrthoDB; 12038at2759; -.
DR Proteomes; UP000008867; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:1990481; P:mRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041708; PUS1/PUS2-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF4; PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 296..400
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 153
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-1"
FT BINDING 215
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR641708-2"
SQ SEQUENCE 570 AA; 63489 MW; 72CE5DA17D3952CD CRC64;
MTERLEQEVG AAATGADPRS LKREFDSEPA TVDTTAQNSA PAEAEASTPK RARFDDAKKK
WERRDRRGTG RVPDDTSSSA DPSSSTGGDR LPKRKVAVKF GYCGIGYSGL QINPGVKTIE
GDIFQAFCTA GAVSADNAVN PNKVGLQRAA RTDRGVHAAG NLLSLKLILQ PDGLQEGETL
VDRVNALLPE FIRVWGVTRV QNGFSARQSC DSRMYEYLLP TYVFVPPKPG STMHDMLVRM
RDDELAKTGA TTLGDVVDHA FWTQHGTTHD FSTDMRAKTA FRLPASALAR IRSIFARYLG
SHNFHNFTVG KEFRDRSCQR FMKQLTISDP TVIGDTEWVS IKFHGQSFML HQIRKMIGLL
VLVGRTGAGE GLVDECFGPA RVHIPKAPGL GLLLEQPIFD AYNTRIRNNN DKIAKLMRKK
ASSDQKDSAP ESADRDAGRN STLHDELRES ISYAPHAAAM QQFKQQWIYD RIHSTEQDTY
EFGKWLNYLD VFQGPDFEFL NPKGVIPPQC IVKVGEFHRD NLRRARESQL GGKEGGGSEQ
QRQQQQDDDD DDEDHEAYSK KGAELDEYEG
//
