ID E6ZZA7_SPORE Unreviewed; 274 AA.
AC E6ZZA7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 13-SEP-2023, entry version 55.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640};
GN ORFNames=sr17110 {ECO:0000313|EMBL:CBQ72564.1};
OS Sporisorium reilianum (strain SRZ2) (Maize head smut fungus).
OG Mitochondrion {ECO:0000313|EMBL:CBQ72564.1}.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Sporisorium.
OX NCBI_TaxID=999809 {ECO:0000313|EMBL:CBQ72564.1, ECO:0000313|Proteomes:UP000008867};
RN [1] {ECO:0000313|EMBL:CBQ72564.1, ECO:0000313|Proteomes:UP000008867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRZ2 {ECO:0000313|Proteomes:UP000008867};
RX PubMed=21148393; DOI=10.1126/science.1195330;
RA Schirawski J., Mannhaupt G., Muench K., Brefort T., Schipper K.,
RA Doehlemann G., Di Stasio M., Roessel N., Mendoza-Mendoza A., Pester D.,
RA Mueller O., Winterberg B., Meyer E., Ghareeb H., Wollenberg T.,
RA Muensterkoetter M., Wong P., Walter M., Stukenbrock E., Gueldener U.,
RA Kahmann R.;
RT "Pathogenicity determinants in smut fungi revealed by genome comparison.";
RL Science 330:1546-1548(2010).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU003640};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}.
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DR EMBL; FQ311469; CBQ72564.1; -; Genomic_DNA.
DR AlphaFoldDB; E6ZZA7; -.
DR EnsemblFungi; CBQ72564; CBQ72564; sr17110.
DR VEuPathDB; FungiDB:sr17110; -.
DR eggNOG; KOG4662; Eukaryota.
DR HOGENOM; CLU_1016253_0_0_1; -.
DR OrthoDB; 1561354at2759; -.
DR Proteomes; UP000008867; Mitochondrion.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU003640};
KW Endonuclease {ECO:0000313|EMBL:CBQ72564.1};
KW Hydrolase {ECO:0000313|EMBL:CBQ72564.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640};
KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:CBQ72564.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640};
KW Nuclease {ECO:0000313|EMBL:CBQ72564.1};
KW Respiratory chain {ECO:0000256|RuleBase:RU003640};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003640};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003640};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640};
KW Ubiquinone {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:CBQ72564.1}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 89..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT REGION 133..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 30747 MW; 442211927401F681 CRC64;
MNTITLFFIF IPILAVILLF ANLLLAVHRP DSEKVTPYEC GFSPVYGQTR NPFSIQFYLV
GILFLVFDIE LLMTYPFAVN LYQTSAYGFW IFVIFFLVLT IGFVYEFGTG ALYFTDKRSS
INNVDVIKSD TSPFTNQKRS YSTSSKNSKS ETNNNEVEKK KKSTYLADAY EKDLGQSTEN
VHLKAQRHIQ SGNPTDHTTI NEVPPHSISI TQEELDKLVS ISPSTILLSD SISEIRKAFQ
AIVGVGRSKL DTKKRVCGVY VFTNLVTGVG AARN
//
