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Database: UniProt
Entry: E7A978_HELFC
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ID   E7A978_HELFC            Unreviewed;        80 AA.
AC   E7A978;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=Translational regulator CsrA {ECO:0000256|HAMAP-Rule:MF_00167};
GN   Name=csrA {ECO:0000256|HAMAP-Rule:MF_00167,
GN   ECO:0000313|EMBL:CBY83305.1};
GN   OrderedLocusNames=Hfelis_12210 {ECO:0000313|EMBL:CBY83305.1};
OS   Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=936155 {ECO:0000313|EMBL:CBY83305.1, ECO:0000313|Proteomes:UP000007934};
RN   [1] {ECO:0000313|Proteomes:UP000007934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49179 / NCTC 12436 / CS1
RC   {ECO:0000313|Proteomes:UP000007934};
RA   Arnold A., Zigova Z., Lawley T., Falkow S., Bentley S., Aslett M.,
RA   Muller A.;
RT   "Comparative whole genome analysis of the carcinogenic bacterial pathogen
RT   Helicobacter felis.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBY83305.1, ECO:0000313|Proteomes:UP000007934}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49179 / NCTC 12436 / CS1
RC   {ECO:0000313|Proteomes:UP000007934};
RX   PubMed=21402865;
RA   Arnold I.C., Zigova Z., Holden M., Lawley T.D., Rad R., Dougan G.,
RA   Falkow S., Bentley S.D., Muller A.;
RT   "Comparative whole genome sequence analysis of the carcinogenic bacterial
RT   model pathogen Helicobacter felis.";
RL   Genome Biol. Evol. 3:302-308(2011).
CC   -!- FUNCTION: A translational regulator that binds mRNA to regulate
CC       translation initiation and/or mRNA stability. Usually binds in the 5'-
CC       UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding,
CC       thus repressing translation. Its main target seems to be the major
CC       flagellin gene, while its function is anatagonized by FliW.
CC       {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SUBUNIT: Homodimer; the beta-strands of each monomer intercalate to
CC       form a hydrophobic core, while the alpha-helices form wings that extend
CC       away from the core. {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SIMILARITY: Belongs to the CsrA/RsmA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00167}.
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DR   EMBL; FQ670179; CBY83305.1; -; Genomic_DNA.
DR   RefSeq; WP_013469669.1; NC_014810.2.
DR   AlphaFoldDB; E7A978; -.
DR   STRING; 936155.HFELIS_12210; -.
DR   GeneID; 36133309; -.
DR   KEGG; hfe:HFELIS_12210; -.
DR   eggNOG; COG1551; Bacteria.
DR   HOGENOM; CLU_164837_0_0_7; -.
DR   OMA; RDESIMI; -.
DR   OrthoDB; 9809061at2; -.
DR   Proteomes; UP000007934; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.4380; Translational regulator CsrA; 1.
DR   HAMAP; MF_00167; CsrA; 1.
DR   InterPro; IPR003751; CsrA.
DR   InterPro; IPR036107; CsrA_sf.
DR   NCBIfam; TIGR00202; csrA; 1.
DR   PANTHER; PTHR34984; CARBON STORAGE REGULATOR; 1.
DR   PANTHER; PTHR34984:SF1; CARBON STORAGE REGULATOR; 1.
DR   Pfam; PF02599; CsrA; 1.
DR   SUPFAM; SSF117130; CsrA-like; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis {ECO:0000256|HAMAP-Rule:MF_00167};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00167};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007934};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00167};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00167};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845, ECO:0000256|HAMAP-
KW   Rule:MF_00167}.
SQ   SEQUENCE   80 AA;  8579 MW;  69F926AC9F895C87 CRC64;
     MLILARKLGE GVVIGEDIYL KVISIDKGSV KLGFQAPLRT LILRSELKEA IATENKKASE
     SVDDSILAGI GKSIRLGKLS
//
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