ID E7E836_OGAPD Unreviewed; 149 AA.
AC E7E836;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640};
GN Name=nad3 {ECO:0000313|EMBL:ADT63567.1};
GN ORFNames=HPOM_12 {ECO:0000313|EMBL:ADT63567.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OG Mitochondrion {ECO:0000313|EMBL:ADT63567.1}.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ADT63567.1, ECO:0000313|Proteomes:UP000008673};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DL-1;
RA El'darov M.A., Mardanov A.V., Beletsky A.V., Ravin N.V., Skryabin K.G.;
RT "Complete sequence and analysis of the mitochondrial genome of the
RT methilotrophic yeast Hansenula (Ogatea) Polymorpha.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADT63567.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=21545683; DOI=10.1111/j.1567-1364.2011.00736.x;
RA Eldarov M.A., Mardanov A.V., Beletsky A.V., Ravin N.V., Skryabin K.G.;
RT "Complete sequence and analysis of the mitochondrial genome of the
RT methylotrophic yeast Hansenula polymorpha DL-1.";
RL FEMS Yeast Res. 11:464-472(2011).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU003640};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}.
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DR EMBL; HQ616673; ADT63567.1; -; Genomic_DNA.
DR RefSeq; YP_004072420.1; NC_014805.1.
DR AlphaFoldDB; E7E836; -.
DR STRING; 871575.E7E836; -.
DR eggNOG; KOG4662; Eukaryota.
DR Proteomes; UP000008673; Mitochondrion.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU003640};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640};
KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ADT63567.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Respiratory chain {ECO:0000256|RuleBase:RU003640};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003640};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003640};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640};
KW Ubiquinone {ECO:0000256|RuleBase:RU003640}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 66..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
SQ SEQUENCE 149 AA; 16997 MW; 020746D0C9FAB733 CRC64;
MFQDLFNIYT ITVGLIGTMF IMVNMLLVES NKMDENNGSS NEYIEKSSPF ECGFDSFKQS
NNPVPVPFII IATLFLPFDL EVTSMLPYII SAYSIGIYGT IIFIMFLLIL VIGFIFELNM
NVISLSKFIK SSQNNNQSYG FNKEIKKYL
//
