ID E7EN11_HUMAN Unreviewed; 441 AA.
AC E7EN11;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit beta 4 {ECO:0000313|Ensembl:ENSP00000380490.3};
GN Name=CACNB4 {ECO:0000313|Ensembl:ENSP00000380490.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000380490.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000380490.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000380490.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC068547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC097448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E7EN11; -.
DR SMR; E7EN11; -.
DR MassIVE; E7EN11; -.
DR PeptideAtlas; E7EN11; -.
DR ProteomicsDB; 17055; -.
DR Antibodypedia; 2810; 382 antibodies from 39 providers.
DR Ensembl; ENST00000397327.7; ENSP00000380490.3; ENSG00000182389.20.
DR UCSC; uc061oqg.1; human.
DR HGNC; HGNC:1404; CACNB4.
DR VEuPathDB; HostDB:ENSG00000182389; -.
DR GeneTree; ENSGT00950000182837; -.
DR HOGENOM; CLU_021995_0_0_1; -.
DR ChiTaRS; CACNB4; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000182389; Expressed in cerebellar vermis and 147 other cell types or tissues.
DR ExpressionAtlas; E7EN11; baseline and differential.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF7; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E7EN11,
KW ECO:0007829|MaxQB:E7EN11};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 45..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 49649 MW; 9347E3780EFC35E6 CRC64;
MAGSADSYTS RPSDSDVSLE EDREAIRQER EQQAAIQLER AKSKPVAFAV KTNVSYCGAL
DEDVPVPSTA ISFDAKDFLH IKEKYNNDWW IGRLVKEGCE IGFIPSPLRL ENIRIQQEQK
RGRFHGGKSS GNSSSSLGEM VSGTFRATPT STAKQKQKVT EHIPPYDVVP SMRPVVLVGP
SLKGYEVTDM MQKALFDFLK HRFDGRISIT RVTADISLAK RSVLNNPSKR AIIERSNTRS
SLAEVQSEIE RIFELARSLQ LVVLDADTIN HPAQLIKTSL APIIVHVKVS SPKEMFDVIL
DENQLEDACE HLGEYLEAYW RATHTTSSTP MTPLLGRNLG STALSPYPTA ISGLQSQRMR
HSNHSTENSP IERRSLMTSD ENYHNERARK SRNRLSSSSQ HSRDHYPLVE EDYPDSYQDT
YKPHRNRGSP GGYSHDSRHR L
//
