ID E7EV13_HUMAN Unreviewed; 500 AA.
AC E7EV13;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN Name=SLC1A6 {ECO:0000313|Ensembl:ENSP00000409386.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409386.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000409386.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000409386.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361216}.
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DR EMBL; AC004659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E7EV13; -.
DR SMR; E7EV13; -.
DR MassIVE; E7EV13; -.
DR MaxQB; E7EV13; -.
DR PeptideAtlas; E7EV13; -.
DR ProteomicsDB; 18548; -.
DR Antibodypedia; 26923; 203 antibodies from 25 providers.
DR Ensembl; ENST00000430939.6; ENSP00000409386.2; ENSG00000105143.13.
DR UCSC; uc010xod.3; human.
DR HGNC; HGNC:10944; SLC1A6.
DR VEuPathDB; HostDB:ENSG00000105143; -.
DR GeneTree; ENSGT00940000159972; -.
DR HOGENOM; CLU_019375_6_5_1; -.
DR ChiTaRS; SLC1A6; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000105143; Expressed in right hemisphere of cerebellum and 99 other cell types or tissues.
DR ExpressionAtlas; E7EV13; baseline and differential.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR11958:SF67; EXCITATORY AMINO ACID TRANSPORTER 4; 1.
DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7EV13,
KW ECO:0007829|ProteomicsDB:E7EV13};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361216};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361216};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 242..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 275..301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 53122 MW; 5C53B00E0C4008B7 CRC64;
MSIDHEQPWQ QPVPAGERPA AGPGGLAAAA AGKPAAESTA HAPAPADHDP RARAALPAPK
RLHSADGQRR GHWGQPGLCP APISAHLPPD QVLLFSWRAS DEDAADAGVT SHCLQPGHRN
MFPPNLVEAC FKQFKTQYST RVVTRTMVRT ENGSEPGASM PPPFSVENGT SFLENVTRAL
GTLQEMLSFE ETVPVPGSAN GINALGLVVF SVAFGLVIGG MKHKGRVLRD FFDSLNEAIM
RLVGIIIWYA PVGILFLIAG KILEMEDMAV LGGQLGMYTL TVIVGLFLHA GIVLPLIYFL
VTHRNPFPFI GGMLQALITA MGTSSSSATL PITFRCLEEG LGVDRRITRF VLPVGATVNM
DGTALYEALA AIFIAQVNNY ELNLGQITTI SITATAASVG AAGIPQAGLV TMVIVLTSVG
LPTEDITLII AVDWFLDRLR TMTNVLGDSI GAAVIEHLSQ RELELQEAEL TLPSLGKPYK
SLMAQEKGAS RGRGGNESAM
//
