ID E7EYQ7_DANRE Unreviewed; 974 AA.
AC E7EYQ7; A0A8M6Z2B6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Transcriptional-regulating factor 1-like {ECO:0000313|Ensembl:ENSDARP00000111755, ECO:0000313|RefSeq:XP_017207228.1};
GN Name=LOC100535969 {ECO:0000313|Ensembl:ENSDARP00000111755,
GN ECO:0000313|RefSeq:XP_017207228.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000111755};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000111755}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111755};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000111755, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000111755};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_017207228.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017207228.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX000363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017207228.1; XM_017351739.2.
DR STRING; 7955.ENSDARP00000111755; -.
DR PaxDb; 7955-ENSDARP00000111755; -.
DR Ensembl; ENSDART00000129100; ENSDARP00000111755; ENSDARG00000088631.
DR Ensembl; ENSDART00000129100.3; ENSDARP00000111755.1; ENSDARG00000088631.3.
DR GeneID; 100535969; -.
DR eggNOG; KOG4167; Eukaryota.
DR HOGENOM; CLU_009800_0_0_1; -.
DR OMA; TSRIYPF; -.
DR OrthoDB; 2906194at2759; -.
DR TreeFam; TF106431; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000088631; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR PANTHER; PTHR16089:SF19; TRANSCRIPTIONAL-REGULATING FACTOR 1; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 399..426
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 610..701
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 716..767
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 870..897
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 362..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 109319 MW; 74BB1933E75067E9 CRC64;
MTENLYETNQ FTNHTNGNYL FQHSPSALSA SHYGLPNMSS IQTSPRLNQE HLMSPGTPGH
ELSPMLDSAG SWEYNPCGRT PSWGSSSHED LQETSRIYPF NVASQNNPLM ICKDNPQRLD
SFSKAFPTKN VHLFFGEMSR DEKMSEIFTQ SHSGALERQS VESPVFNQQL MCDQSNFNMS
DSLYQNHQQL HYGYQQKQKA NNMEQVNRNL HKSSWHPSHG YQSHPMAYQM ALGQQQRCMF
ANKTHLDSWE SLESPSYEHR QDFKVPEQQI FHYQDQQQHL RSLSQNANPY LQSPDQPVEQ
NSMFGDARNS APNTLVFSSP NKDQSGFSFR SDDLYQGKSS AVCKAPPQTG VRGDVLKHFT
QRASQWSKAS SPDVKDEAAS PHFRADAGLS RDEGSYAKMK CTVCLREFKS LPALNGHMRS
HGGLRTHPAN LKMRDGQMNM CAEVPQGNPI ILPVSVPVKN YQTQTKLTLL CQQKDDGLIK
SCAQTPLPPL RNHPSCIKRS NSEGESAPKQ VKKKYRHCLV PLMIPSPSDG QESRGAVLFR
SQLRTASSMS DDAPYTPPPM LSPARPGSGL FSAVSGRANI QSTPERLLSR AGEMDDCGET
LKETAINVTP RINIGEEFQA KIPNIKGQSL TEEDSHNAVL LWSQTKDMES PDNQHKVDNL
LKMACSSVLP GGGANTEYVL HCLFECRGDI MNTVEKLLLP TLIRHTSNLK TDYHYAGSDR
WTLQEKRQLN KALLLHHKDF YLVQKMVKTK SVAQCVEYYY TWKKRLRLCS RVSTALATPV
QDVRGDWATN NHSEPKKESI SKSRDSENSS AAFVCETNEE TWTQNNLRLL CSSPAEHRPS
ALTETLGSAS VRSSPSNSTT SGDTDLALVF PCTECGKVFL KVKSRNAHMK THRQQEETLL
WHFTGVPKQD HAIVTPGCPV TPLKEPIRLH PLSYHSNTEA KTSLNDMCSE SEQEMDCSLK
SLPVLQSRLN FMSS
//
