ID E7EZI3_DANRE Unreviewed; 1310 AA.
AC E7EZI3; A0A8M1PUN3;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Contactin-associated protein family member 5-like {ECO:0000313|Ensembl:ENSDARP00000098177};
DE SubName: Full=Contactin-associated protein-like 5 isoform X1 {ECO:0000313|RefSeq:XP_001338473.5};
GN Name=cntnap5l {ECO:0000313|Ensembl:ENSDARP00000098177,
GN ECO:0000313|RefSeq:XP_001338473.5,
GN ECO:0000313|ZFIN:ZDB-GENE-140106-102};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000098177};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000098177}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098177};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000098177, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000098177};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_001338473.5}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_001338473.5};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in the correct development and proper
CC functioning of the peripheral and central nervous system and be
CC involved in cell adhesion and intercellular communication.
CC {ECO:0000256|ARBA:ARBA00003165}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BX119916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU019552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU633811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001338473.5; XM_001338437.8.
DR STRING; 7955.ENSDARP00000098177; -.
DR PaxDb; 7955-ENSDARP00000098177; -.
DR Ensembl; ENSDART00000111193; ENSDARP00000098177; ENSDARG00000073802.
DR Ensembl; ENSDART00000111193.5; ENSDARP00000098177.4; ENSDARG00000073802.5.
DR GeneID; 798019; -.
DR KEGG; dre:798019; -.
DR AGR; ZFIN:ZDB-GENE-140106-102; -.
DR CTD; 798019; -.
DR ZFIN; ZDB-GENE-140106-102; cntnap5l.
DR eggNOG; KOG3516; Eukaryota.
DR OrthoDB; 4255614at2759; -.
DR TreeFam; TF321823; -.
DR Proteomes; UP000000437; Chromosome 11.
DR Bgee; ENSDARG00000073802; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF46; CONTACTIN-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1310
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157040"
FT TRANSMEM 1241..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..175
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 181..362
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 369..548
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 550..587
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 795..960
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 961..998
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1021..1204
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 42..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 933..960
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1310 AA; 146035 MW; B542FE09BE612046 CRC64;
MRFLSSIGMF VLTTLSALTS VLSASNYYCE EPLLTSLPTS SFRNSSKYSD RRSPHYAKLN
RRDGGGGWSP SGEDQQPWLQ LDLRDRLKVT SIATQGRWGS SDWVARYQLH YSDSGRTWRP
YRQEDVIWTF TGNSDTDTVV QHKLPHSIRT RYMRLLPIEG SPRGGMGLRL EVYGCTYKSD
VADFDGRSAL LYRFNQKSTS TVKDVISLRF RSHQAEGVLV HGEGQRGDFL TLELQRGRLI
LHLNLDDAKP QSGGRSSSVM LGSLLDDHHW HSVQIERFNK HVNFTVDGHT QHFRSLGQED
TLEIDYELSF GGIPLPGKPG TFLHENFHGC IENLNYNGVN VIDMAKRRKP QIYTVGNVTF
SCSESSSVAV TFLSSTGSFL ALPADYSMDS LSVRLQFRTW NQEGLLFSVP LSHDPDPINL
LLRLSQARLL LLLSGGPQNS AQVFSGQNLN DGQWHSISVE VKGEKVSLTV NNQKPATMEI
TGRSQTPQRT TIYIGGCPLF QSNFNCENPG RGYQGCFRLL LINNHPVNFL QIQQENMGNF
SQISFDVCNI QDRCLPNLCE HGGQCIQSWD QFDCNCSGTG YTGATCHNSI YERSCEAFRK
TGSQSSVFTI DLDGSGLLDH AQVNCTVAED KVWTVVGHDH MRPIDIRGST PRSPFVLIFN
YTISPYHLRS LVTSSEHCQQ EVIYRCRKSR LFDTWDGTPL SWWLDRDGVK RTYWGGFLPG
VQQCSCSLDG NCRDMNYFCN CDADQDTWAN DTGVLSYKDH LPLSEIAIGD TNRTNSQAEL
QIGPLRCYGN RFFWNSASFY QESSYLHFPT LQAELSIDIS LFFKTSAFSG VFLENLGVRD
FVRLELSSPS TMNFTFDLGD GPVTLTVRSP VALNDRQWHY IRAERNVKEA SLQVDSLPLE
LTEAPPEKPY RLQLSSQLFV GGTASRQRGF VGCLRALTIN GVTLDLFERA KTTPGVNSGC
PGHCTSDSVC HNGGRCVEER SSYACDCTQT AFDGPHCRKA LAASFESGSS VLYTLQEPFS
GILNEEARRS PAGFHDAEVA KSQEKVSFGF LTRHVPALIL MAHTLDQNYM AVMLTSNGSL
QIRYLMNKEK RTEMFSPKSG SLADGRFHWV KINRKGQELL VQIDNTITQQ YSLSPGSALS
PVRSVILGRI QGSDITDKEL VQAGLRGFIG CLSSVQFNQA TPLKAALQNS PLVTVIGHLE
ASSCGTISSP NTLSDTHIRS DDSAKSDRGK DPPKKADQND LALIGGVVAA VVFITLCALA
FIIRFLYRHR RTPAPSGITG KMHRPSIEPP PYRAALDLHK PHHDSKEYYI
//
