ID E7F0M4_DANRE Unreviewed; 1104 AA.
AC E7F0M4; A0A8M3AT85;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Formin-like 2b {ECO:0000313|Ensembl:ENSDARP00000102294};
DE SubName: Full=Formin-like protein 2 isoform X2 {ECO:0000313|RefSeq:XP_009300534.1};
GN Name=fmnl2b {ECO:0000313|Ensembl:ENSDARP00000102294,
GN ECO:0000313|RefSeq:XP_009300534.1,
GN ECO:0000313|ZFIN:ZDB-GENE-041111-182};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000102294};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000102294}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000102294};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000102294, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000102294};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009300534.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009300534.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR EMBL; CR853290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU639420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO704767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009300534.1; XM_009302259.3.
DR PaxDb; 7955-ENSDARP00000102294; -.
DR Ensembl; ENSDART00000112883; ENSDARP00000102294; ENSDARG00000075041.
DR Ensembl; ENSDART00000112883.4; ENSDARP00000102294.3; ENSDARG00000075041.5.
DR GeneID; 492608; -.
DR AGR; ZFIN:ZDB-GENE-041111-182; -.
DR CTD; 492608; -.
DR ZFIN; ZDB-GENE-041111-182; fmnl2b.
DR eggNOG; KOG1923; Eukaryota.
DR HOGENOM; CLU_003597_0_0_1; -.
DR OrthoDB; 471257at2759; -.
DR TreeFam; TF325155; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000075041; Expressed in gastrula and 40 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0060857; P:establishment of glial blood-brain barrier; IMP:ZFIN.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF1; FORMIN-LIKE PROTEIN 2 ISOFORM X1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7F0M4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 24..469
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 633..1024
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 381..478
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 181..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 125195 MW; C388DDAC28F8E0AD CRC64;
MGNAESMDAQ LTDFRARGSK PPKLPMPDPA ELEERFAIAL NTMNLPPDKV RILRQYDNEK
KWELICDQER FQVKNPPHTY IQKLRSFLDP AVTRKKFRRR VQESTQVLRE LEISLRTNHI
GWVREFLNEE NKGLDVLVEY LSFAQYAVTF DGDVAESATG EISVETPWSR SIEDLHGDSN
LPSPVSGSSI PRSTRHSLRS NTLPSRRTLK NSRLVCKKDD VHVCIMCLRA IMNYQYGFNM
VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILAAFDHF KEVCSETQRF
EKLMEHFKNE DNNIDFMVAC MQFINIVVHS VEDMNFRVHL QYDFTKLSLD DYLERLKHTE
SDKLKVQIQA YLDNLFDVGT LLEDAETKNA ALERVEELEE NLSHMSDKLL ETENEAMSKI
VELEKQLMQK NKELDTVRAV YRDASSQVHT LRRIVREKDE TIQKQSTLEK KIHELERRGS
LQIQVRGEGD GEGDVSPLPS PPQPMALSPC PDAMALAGAC AGASYSSASS SQTGTLRAMV
TPPPPPPPPP PMTDSSVPNG PSAALPPPPP PPPPPPPPPP PPPPPPGHSI EISAPLPPPP
PPCAPPLPGS GTPTVIFNSG LTDGPIKLFS VKIKKPIKTK FRMPVFNWVA LKPNQINGTV
FNEIDDERIL EDLNVDEFEE MFKTKAQGPA VDMTLQKQKA PQKGPNKVSL LEANRAKNLA
ITLRKAGKSP EEICKAIQTF DLRTVPVDFV ECLMRFMPTE SEVKVLRQYE RERRPMDGLT
DEDRFMMLFS KIERLPQRMT IMAFMGNFTD SLQMLTPQLH AIIAASVSIK SSQKLKKILE
IILALGNYMN SSKRGAVYGF KLQSLDLLLE TKSTDRKQTL LHYIANVVKE KYPIVSIFYN
ELHYIEKAAA VSLENVLLDV RELQRGMDLT KREYSMHGHN SLLKDFIHHN EARLKKLLDD
AKIAQDAFDE AVKFFGESAK TMPPSVFFPV FVRFIKSYRQ ADEENELRKR QEQLMMEKLM
EQEAMMEEQE SQQSPSHKGK RQQQELIHEL RKRQGKDSRL VYEGKDGAIE DIITVLKTAP
FTARSAKRGS RFFCDPALSE DFHY
//
