ID E7F1C8_DANRE Unreviewed; 599 AA.
AC E7F1C8; A0A8M1RLY4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Integrin alpha FG-GAP repeat-containing 1 {ECO:0000313|Ensembl:ENSDARP00000104242};
DE SubName: Full=T-cell immunomodulatory protein isoform X1 {ECO:0000313|RefSeq:XP_002662910.3};
GN Name=itfg1 {ECO:0000313|Ensembl:ENSDARP00000104242,
GN ECO:0000313|RefSeq:XP_002662910.3,
GN ECO:0000313|ZFIN:ZDB-GENE-121003-3};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000104242};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000104242}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000104242};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000104242, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000104242};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_002662910.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_002662910.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TIP family. {ECO:0000256|ARBA:ARBA00006496}.
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DR EMBL; CR759753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR847539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO018320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002662910.3; XM_002662864.5.
DR STRING; 7955.ENSDARP00000104242; -.
DR PaxDb; 7955-ENSDARP00000104242; -.
DR Ensembl; ENSDART00000110907; ENSDARP00000104242; ENSDARG00000075584.
DR Ensembl; ENSDART00000110907.5; ENSDARP00000104242.2; ENSDARG00000075584.5.
DR GeneID; 100331534; -.
DR KEGG; dre:100331534; -.
DR AGR; ZFIN:ZDB-GENE-121003-3; -.
DR CTD; 81533; -.
DR ZFIN; ZDB-GENE-121003-3; itfg1.
DR eggNOG; KOG4550; Eukaryota.
DR HOGENOM; CLU_020272_2_0_1; -.
DR OMA; PGDWIPW; -.
DR OrthoDB; 5477979at2759; -.
DR PhylomeDB; E7F1C8; -.
DR TreeFam; TF105620; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000075584; Expressed in retina and 20 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR024881; Tip.
DR PANTHER; PTHR13412:SF0; T-CELL IMMUNOMODULATORY PROTEIN; 1.
DR PANTHER; PTHR13412; T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG; 1.
DR Pfam; PF13517; FG-GAP_3; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7F1C8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..599
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157615"
FT TRANSMEM 553..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 599 AA; 66827 MW; 26379C878FB7352D CRC64;
MLLSFACFLT LLSSFVGQHV TFALQDVTSD LFGQENNGTV AAFGDFNSDK QTDIFIIRKQ
SELLIFLADL KAPYFKPKVH LTKEVFPSDF IISSVVPGDY DGDSQMDVLL TGHLNGSPLQ
TSVFVFWGRN QTLDQNKKEK LDKIFTDQPL VMDFDGDMIP DIFGTVDGSL EVCYLKARQQ
RCEKALNSTV AMRIPHSHAF IDLNKDFTAD LFLTTTSNEF ETWINKDGNF TKAPSGPSLE
NVKRVGQSAF VDFDGDGFQD HLLPVCMDDA CAKSAIYLAR PGGTKWVPVL MDFKRKDSVW
GFVPAPEKPT SEELRIPITL HLGDYNLDGF PDALVILRNT SASSQQQAFL LENVACNDAS
CQEAERMFRV HWEQSDLSAI PRAVVATFFD IYEDGILDMI VLSKVEGKEE LVIHALKNNF
EADAYFVKVI VLSGLCSNDC PEKVKPFGVN QPGPYVMYTS VDSNGYLKNA SAGQLSQSAH
LALQLPYTVL GLGRSANFLD HLFVGIPRPP GGKDVRKQEW TAIIPNSQLI VIPYPQNEPR
SWSAKLYLTP SNIVLLTAIA LIGVCIFILV IIGILHWQEK KADDREKRQE AHRFHFDAM
//
