ID E7F1J4_DANRE Unreviewed; 1288 AA.
AC E7F1J4; A0A8M1Q7I4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=DENN domain-containing protein 5A isoform X3 {ECO:0000313|RefSeq:XP_001340162.4};
DE SubName: Full=DENN/MADD domain-containing 5A {ECO:0000313|Ensembl:ENSDARP00000060544};
GN Name=dennd5a {ECO:0000313|Ensembl:ENSDARP00000060544,
GN ECO:0000313|RefSeq:XP_001340162.4,
GN ECO:0000313|ZFIN:ZDB-GENE-071211-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000060544};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000060544}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060544};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000060544, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000060544};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_001340162.4}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_001340162.4};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; BX571980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO018393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001340162.4; XM_001340126.8.
DR STRING; 7955.ENSDARP00000060544; -.
DR PaxDb; 7955-ENSDARP00000060544; -.
DR Ensembl; ENSDART00000060545; ENSDARP00000060544; ENSDARG00000017006.
DR Ensembl; ENSDART00000060545.7; ENSDARP00000060544.5; ENSDARG00000017006.10.
DR GeneID; 799847; -.
DR KEGG; dre:799847; -.
DR AGR; ZFIN:ZDB-GENE-071211-1; -.
DR CTD; 23258; -.
DR ZFIN; ZDB-GENE-071211-1; dennd5a.
DR eggNOG; KOG2080; Eukaryota.
DR HOGENOM; CLU_004201_2_0_1; -.
DR OMA; KVTQEMY; -.
DR OrthoDB; 5398783at2759; -.
DR PhylomeDB; E7F1J4; -.
DR TreeFam; TF313237; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000017006; Expressed in retina and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0050933; P:early stripe melanocyte differentiation; IMP:ZFIN.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17690; RUN1_DENND5A; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047294; RUN1_DENND5A.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7F1J4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..599
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 788..952
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 956..1064
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1135..1283
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 161..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 147373 MW; F5426915FE8819ED CRC64;
MSTGFSSSSC RFADYFVICG LDTESGLEPD ELSALCQYIQ ATKFTDGARG KLASANEGEN
FEQSPLRRTF KSKVLAHYPD NVEWNPFDQD AVGMLCMPKG LSFRTQTDTR EPQFHSFIIT
REDGSRTYGF ALTFFEEVTS KQICSAMQTL YHMHNAEQYD ILHTPPTPRS PEDPRPTTQQ
LHASPALSRL QRFNSYDISR DTLYVSKCIC LITPMAFAHA CRKVLEQLHQ AVTSPQPPPL
PLESYVYNVL YEVPLPPAGR SLKFSGVYRP VICQRPSTAE LPLFDFPLQE VFELLGLENI
LQLFTCALLE IQILLYSQHY QRLMTVAESI TALMFPFQWQ HVYVPILPAS LLHFLDAPVP
YLMGLHSNGQ DDRTKLELPQ EANLCFVDID NHFIELPEDL PQFPNKLEFI QEISEVLLAF
GLSPEANPQC SEGQSKIRGF RCGDMASDKR NGNLAGSPLN SFLLRENQTI ARLQALVKRT
GVSLEKLDVK DDASTNKDTK VQCEEEEMKM HQLNIRVREV FANRFSQMFS DYEVFVIQPS
QDKESWFSNR DQMQNFDKAS FLSDQPEPYL PFLSRFLETQ MFASFIDSKI LCHDDEDKEH
TLRVFDSRVD KIRMINVRTP TLRTSMYQKC TNIDEAEKAI EVRLCKIDHT ALHPHLLDMK
IGQGRYEPGF FPRLQSDVLS TGPTSNKWAK RSAPAQWRRK DRQKQHAEHL YLDNDQREKY
IQEARNLGTT LRQPKLSNLS PSVIAQTNWK FVEGLLKECR NKTKRMLVEK MGREAVELGH
GEVSITGVEE NTLIASLCDL LERIWSHGLQ VKQGKSALWS HLLHYQESKE KRDATPAGLG
PPGIIHDTER RKSDASCAMP PLKVSLIQDM RHIQNISEIK TDVGKARAWV RLSMEKKLLS
RHLKQLLSDH ELTKKLYKRY AFLRCDDEKE QFLYHLLSFN AVDYFCFTNV FTTIMIPYHV
VIIPSKKLGG SMFTANPWVC VSGELAETGV LQVPKNTLEI TFECQNLGKL TTVQMGHDNS
GLYAKWLVEC VMVRNGITGH TYKFPCGRWL GKGVDDGSLE RILVGELVTN MESDERMCRT
PPMQQSPGMM RRFVTISPNS KPKLNTGQIQ ESVGEAINGI VKHFHKPEKE RGSLTLLLCG
EYGLVWALEQ VFQHGFKSPR LFKNVFIWDF LEKAQVYFES AERSQMTQDE NWQMRVRHFC
HFMRAINSTP RNIGKDGKFQ MLVCLGARDH LLHHWIALLA ECPITAQMYE DVALLKDHSL
VNSLIRVLQT LQEFNITLEA SLVKGIGI
//
