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Database: UniProt
Entry: E7F1N1_DANRE
LinkDB: E7F1N1_DANRE
Original site: E7F1N1_DANRE 
ID   E7F1N1_DANRE            Unreviewed;       539 AA.
AC   E7F1N1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-OCT-2019, entry version 67.
DE   SubName: Full=Potassium inwardly rectifying channel subfamily J member 3b {ECO:0000313|Ensembl:ENSDARP00000065371};
GN   Name=kcnj3b {ECO:0000313|Ensembl:ENSDARP00000065371,
GN   ECO:0000313|ZFIN:ZDB-GENE-120215-38};
GN   Synonyms=si:dkey-114o13.3 {ECO:0000313|ZFIN:ZDB-GENE-120215-38};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000065371, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000065371}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065371};
RG   Ensembl;
RL   Submitted (APR-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000065371, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065371,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; CR847926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005165913.1; XM_005165856.3.
DR   STRING; 7955.ENSDARP00000065371; -.
DR   PaxDb; E7F1N1; -.
DR   Ensembl; ENSDART00000065372; ENSDARP00000065371; ENSDARG00000062217.
DR   GeneID; 557095; -.
DR   KEGG; dre:557095; -.
DR   CTD; 557095; -.
DR   ZFIN; ZDB-GENE-120215-38; kcnj3b.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193368; -.
DR   InParanoid; E7F1N1; -.
DR   KO; K04997; -.
DR   OMA; KMNSERF; -.
DR   OrthoDB; 956263at2759; -.
DR   PhylomeDB; E7F1N1; -.
DR   TreeFam; TF313676; -.
DR   Reactome; R-DRE-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-DRE-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   Proteomes; UP000000437; Chromosome 6.
DR   Bgee; ENSDARG00000062217; Expressed in 7 organ(s), highest expression level in brain.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     76    100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    112    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       39    179       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      186    355       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      517    539       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   539 AA;  59873 MW;  F22D769F22EBDE5D CRC64;
     MSALRKKFGD DYQVVTTSSS GGGFNQAAPE KKRKRQRFVD KNGRCNVQHG NLGGETSRYL
     SDLFTTLVDL KWRWNLFIFI LTYTVAWLFM ASMWWVIAFI RGDMNQAHDD KYTPCVANVY
     NFPSAFLFFI ETEATIGYGY RYITDKCPEG IILFLFQSIL GSIVDAFLIG CMFIKMSQPK
     KRAETLMFSE HAAISMRDGK LTLMFRVGNL RNSHMVSAQI RCKLLKSRQT PEGEFLPLDQ
     LELDVGFSTG ADQLFLVSPL TICHVIDSKS PFYDLSLRSM QTEQFEIVVI LEGIVETTGM
     TCQARTSYTE DEVLWGHRFY PVISLEEGFF KVDYSQFHGT FEVPTPPHSV KEQEESLLLS
     SPLTAPSLCH SAGGVTEGSG TLEGLELQSD AETGSINIAT PMPTNKLPAK LQKLTGREVP
     IRDGMPRKLL RMSSEITYNL GDLPVKLQRI SSAPGVAEER LQPISSMLSP TEDRLAPKLG
     LIGGAETISQ SVTDLPPKLQ RLAGGVGVGG VGIGGRMDGH LPPKLRKMNS ERFTGLSLK
//
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