ID E7F1V3_DANRE Unreviewed; 893 AA.
AC E7F1V3; A0A8M1NCW1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=TBC domain-containing protein kinase-like protein {ECO:0000313|RefSeq:NP_001074106.2, ECO:0000313|RefSeq:XP_005160158.1};
DE SubName: Full=TBC1 domain-containing kinase {ECO:0000313|Ensembl:ENSDARP00000109057};
GN Name=tbck {ECO:0000313|Ensembl:ENSDARP00000109057,
GN ECO:0000313|RefSeq:NP_001074106.2, ECO:0000313|RefSeq:XP_005160158.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070112-1062};
GN Synonyms=im:7138354 {ECO:0000313|RefSeq:NP_001074106.2,
GN ECO:0000313|RefSeq:XP_005160158.1}, wu:fc74a10
GN {ECO:0000313|RefSeq:NP_001074106.2,
GN ECO:0000313|RefSeq:XP_005160158.1}, zgc:158710
GN {ECO:0000313|RefSeq:NP_001074106.2,
GN ECO:0000313|RefSeq:XP_005160158.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000109057};
RN [1] {ECO:0000313|RefSeq:NP_001074106.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074106.2};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|RefSeq:NP_001074106.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074106.2};
RX PubMed=21873635;
RA Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.;
RT "Phylogenetic-based propagation of functional annotations within the Gene
RT Ontology consortium.";
RL Brief. Bioinform. 12:449-462(2011).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000109057}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109057};
RG Ensembl;
RL Submitted (APR-2011) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000109057, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000109057};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001074106.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074106.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001074106.2, ECO:0000313|RefSeq:XP_005160158.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001074106.2,
RC ECO:0000313|RefSeq:XP_005160158.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX537118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR387924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR854985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001074106.2; NM_001080637.2.
DR RefSeq; XP_005160158.1; XM_005160101.4.
DR STRING; 7955.ENSDARP00000109057; -.
DR PaxDb; 7955-ENSDARP00000109057; -.
DR Ensembl; ENSDART00000125099.5; ENSDARP00000109057.3; ENSDARG00000013667.13.
DR Ensembl; ENSDART00000175142.2; ENSDARP00000143948.1; ENSDARG00000013667.13.
DR GeneID; 791155; -.
DR KEGG; dre:791155; -.
DR AGR; ZFIN:ZDB-GENE-070112-1062; -.
DR CTD; 93627; -.
DR ZFIN; ZDB-GENE-070112-1062; tbck.
DR eggNOG; KOG1093; Eukaryota.
DR HOGENOM; CLU_011160_0_0_1; -.
DR OrthoDB; 122047at2759; -.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000013667; Expressed in mature ovarian follicle and 21 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF87; TBC1 DOMAIN CONTAINING KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00450; RHOD; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Kinase {ECO:0000313|RefSeq:NP_001074106.2,
KW ECO:0000313|RefSeq:XP_005160158.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7F1V3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|RefSeq:NP_001074106.2,
KW ECO:0000313|RefSeq:XP_005160158.1}.
FT DOMAIN 1..273
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 466..651
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 790..889
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
SQ SEQUENCE 893 AA; 100970 MW; 71C04562BC0C95C3 CRC64;
MQPLRDAELG ASTFFASPLP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS
RGKHERLVIV AEHYEKSLKD LLKQRKPVSP EKVLQVAYEV LEGLEFMNKH GMVHRALSPN
NVLLDRADKV KLAKFGLYHM TDHGADVDFP IGYPSYLPPE VIAQGCFYSS EPSINEAPQP
SGPKTDVWSL GVLLFELCVG RQILQNIDIS ERMKFIITLG CMDDIITVLA EEHGCIDTIK
DLPENVQALL RKCLTFLPSK RPTPSDLLGD AVFESISSEY TPYQSPVHLF SASPRCAYLQ
LPDDISELCR ENGENYLSER AIDEVYHLWC LAGGDLEKEL TNQEIIQSKP PICTLPKFIL
EDGESFGQGR DRSFLLDDTT VTLSLFQLRN RLKDVAGETY FPLLEDEQCS LPQSSSSNEL
SATVTLPLII RERDTEYQLT RIVLFHRLLK AYPYKKNQIW KEARVDIPPL LRGLAWAALL
GVEGDIQSKY DSIDKDTPIP TDRQIEVDIP RCHQYDELLS SPQGHVKFRR VLKAWVVSHP
DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM
IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV
AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPNKPP
SESNSFGKTP SYYASEFQEL TKTDLSREPL KLSELKAEVS PRISVEDLID LCELSGPAFF
KTPVKRARTG KPKILAVDIR SLEDFSRGHI YGSINIPYTS TFGPEGELLQ CPASSSLAGY
RLRVIVILSS VMKNAITFAT HLVKVNFPRV CVLDGGMNKM KSTGLLTVPS PQI
//
