ID E7F2Z9_DANRE Unreviewed; 732 AA.
AC E7F2Z9; A0A8M3B756;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Si:dkey-94l16.4 {ECO:0000313|Ensembl:ENSDARP00000126627};
GN Name=si:dkey-94l16.4 {ECO:0000313|Ensembl:ENSDARP00000126627,
GN ECO:0000313|RefSeq:XP_009304640.1,
GN ECO:0000313|ZFIN:ZDB-GENE-121214-291};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000126627};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000126627, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000126627};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000126627}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000126627};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_009304640.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009304640.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX000348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009304640.1; XM_009306365.3.
DR STRING; 7955.ENSDARP00000126627; -.
DR PaxDb; 7955-ENSDARP00000111289; -.
DR Ensembl; ENSDART00000152272; ENSDARP00000126627; ENSDARG00000090142.
DR Ensembl; ENSDART00000152272.2; ENSDARP00000126627.1; ENSDARG00000090142.4.
DR GeneID; 101885814; -.
DR KEGG; dre:101885814; -.
DR AGR; ZFIN:ZDB-GENE-121214-291; -.
DR ZFIN; ZDB-GENE-121214-291; si:dkey-94l16.4.
DR eggNOG; KOG1084; Eukaryota.
DR HOGENOM; CLU_355120_0_0_1; -.
DR OMA; HETEHWF; -.
DR OrthoDB; 2919570at2759; -.
DR TreeFam; TF316155; -.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000090142; Expressed in retina and 20 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd15668; ePHD_RAI1_like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14955; RETINOIC ACID INDUCED 1/TRANSCRIPTION FACTOR 20; 1.
DR PANTHER; PTHR14955:SF8; TRANSCRIPTION FACTOR 20; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR PROSITE; PS51805; EPHD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 610..723
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 258..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 80158 MW; C2B07A729170FC35 CRC64;
MEEAPSSSDA LQPQDLSSAC SLPDIECLLK ANPIDALRVV PTPAWILGPG TSNGILLSES
DSEPTIPAGQ IQPDEAFSNT TVTLSYVSRS HLFSEHSPVY GVPSAFLRAY DAGKLAADAG
DVDCVQQVSV PLGLTTCEQL GFLTPEQVVE NMAALCYLQQ PDVENLALET LKSLQANPGE
CRFPISVDEL QNGAANGLWS VNPFQGGFPE ENGGDVEGLH PNVNPELVLL ISRSEEPLIL
PNEATSFALS LNPEFVSPLD SALPSEEQTQ DDSAQNATPP SGLMNDAMQK EAIEVMNSSS
CVKLTKQTEN DASDAFKTSD DLVIKTKKIP ERKTLPPRAG RGMRLEAIVQ NMQLFRCKST
RVVKPRGTNK PSRVKTHNSV LAEKTEVQHV HTEPTEVRRS SRRKATISTS TPVKTFLKCT
KNESTNRNCS SLTSNQGNQA VHKHNVSIKK SVKRKNKKCK STPFFSAQEP EINLKCLKLK
KKEVRDDSFA PYVRVQFSNC TIVNYPNEKR GKSKTSAGFL SGITPATPGF QHGRVSMDGE
HQDLLVCCLC GSSSNAMDLG DLHGPYYAEG FKPASKVASN HQEDENSDSD SSFRGKTAAE
GNWTDSLDWR WSGVGEPARR VRTDSPIDWY SPPVVPLHET EHWFHEDCAI WSAGVFLVRG
KLYGLENAVK LAKVSVCSTC QRTGATLGCV YKGCLNKYHY TCAVQSGCVL NEDNYSMKCR
KHKNSSYHQI NR
//
