ID E7F6D6_DANRE Unreviewed; 751 AA.
AC E7F6D6; A0A8M2BAK7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=AFG3-like protein 1 {ECO:0000313|RefSeq:XP_005163264.1};
DE SubName: Full=Si:ch1073-174d20.2 {ECO:0000313|Ensembl:ENSDARP00000127080};
GN Name=afg3l1 {ECO:0000313|ZFIN:ZDB-GENE-121214-51};
GN Synonyms=si:ch1073-174d20.2 {ECO:0000313|RefSeq:XP_005163264.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000127080};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000127080, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127080};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000127080}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127080};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005163264.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005163264.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR EMBL; FP245543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FP312612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005163264.1; XM_005163207.4.
DR STRING; 7955.ENSDARP00000127080; -.
DR PaxDb; 7955-ENSDARP00000127080; -.
DR PeptideAtlas; E7F6D6; -.
DR Ensembl; ENSDART00000152240; ENSDARP00000127080; ENSDARG00000079651.
DR Ensembl; ENSDART00000152240.2; ENSDARP00000127080.1; ENSDARG00000079651.5.
DR GeneID; 570430; -.
DR KEGG; dre:570430; -.
DR AGR; ZFIN:ZDB-GENE-121214-51; -.
DR CTD; 114896; -.
DR ZFIN; ZDB-GENE-121214-51; afg3l1.
DR eggNOG; KOG0731; Eukaryota.
DR HOGENOM; CLU_000688_16_2_1; -.
DR OMA; YDKQGGG; -.
DR OrthoDB; 9585at2759; -.
DR PhylomeDB; E7F6D6; -.
DR TreeFam; TF105004; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000079651; Expressed in heart and 19 other cell types or tissues.
DR GO; GO:0005745; C:m-AAA complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0034982; P:mitochondrial protein processing; IBA:GO_Central.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655:SF7; AFG3-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7F6D6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 100..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 292..431
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 56..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 83001 MW; 23277C7A1C58FE5B CRC64;
MAALLSASLR GAARTALRFH TARIRSCAAH PPFSGLYGVS PLRSVGKRFT FPQSCYSTDA
PKDAPPPGGG GGGRRGGRKS WPARLAQGDF PWDDRDFRHL LLAASGVAAL LLYLLFRDPG
KEITWKDFVH RYLDRGLVER LEVVNKQFVR VILERDADAN EGSYVWFNIG SVDTFERNLE
AAHYELGLEP SHRAAVVYTS ESDGSFLMSF IPTLLLIGFL LFTLRRGPMG GGMGGRRGGL
FGMSESTAKM MKDSIEVKFK DVAGCEEAKV EIMEFVNFLK NPQQYQDLGA KIPKGAVLSG
PPGTGKTLLA KATAGEANVP FITVNGSEFL EMFVGVGPAR VRDMFALARK NAPCILFIDE
IDAVGKKRGG GNFGGNSEQE NTLNQLLVEM DGFNSSTNVV VLAGTNRPDV LDPALMRPGR
FDRQIYLGPP DIKGRASIFK VHLRPLKLDP SVDRDAIARK MAAATPGFTG ADIANVCNEA
ALIAARYLNE SVSVKHFEQA IDRVIGGLEK KTQVLQPTEK KTVAYHEAGH AVVGWFLQHA
DPLLKVSIIP RGKGLGYAQY LPKEQYLYTR EQLFDRMCMM LGGRVAEQVF FNKITTGAHD
DLKKVTQSAY AQIVQFGMSE RVGQVSFDLP RQGETVLEKP YSEATAELID EEVRDLVDRA
YRRTLELVTE KREQVDMVGK RLLEKEVLDK ADMLELLGAR PFEEKSTYEE FVEGTGSFEE
DTSLPEGLKD WNQERRGEPE EPTDSQEQRA A
//