GenomeNet

Database: UniProt
Entry: E7F7Y0_DANRE
LinkDB: E7F7Y0_DANRE
Original site: E7F7Y0_DANRE 
ID   E7F7Y0_DANRE            Unreviewed;      1612 AA.
AC   E7F7Y0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   05-JUN-2019, entry version 70.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000137521};
GN   Name=zmp:0000000660 {ECO:0000313|Ensembl:ENSDARP00000137521};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000137521, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000137521, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137521,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000137521}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137521};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; CR387919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR848055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU571397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU929428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009301838.1; XM_009303563.2.
DR   RefSeq; XP_009301839.1; XM_009303564.2.
DR   RefSeq; XP_688145.6; XM_683053.8.
DR   STRING; 7955.ENSDARP00000073276; -.
DR   PaxDb; E7F7Y0; -.
DR   Ensembl; ENSDART00000172619; ENSDARP00000137521; ENSDARG00000100518.
DR   Ensembl; ENSDART00000184113; ENSDARP00000145552; ENSDARG00000100518.
DR   GeneID; 559690; -.
DR   KEGG; dre:559690; -.
DR   CTD; 559690; -.
DR   eggNOG; KOG1117; Eukaryota.
DR   eggNOG; COG5347; LUCA.
DR   GeneTree; ENSGT00940000167169; -.
DR   KO; K18440; -.
DR   OMA; ASIVAHC; -.
DR   OrthoDB; 98944at2759; -.
DR   Reactome; R-DRE-194840; Rho GTPase cycle.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000100518; Expressed in 12 organ(s), highest expression level in zone of skin.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 5.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 4.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 5.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN        2     66       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   DOMAIN      416    508       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      521    610       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      607    741       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      821    931       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      942   1040       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN     1044   1225       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN     1254   1347       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     1361   1464       PH. {ECO:0000259|PROSITE:PS50003}.
FT   REGION       86    106       Disordered. {ECO:0000256|MobiDB-lite:
FT                                E7F7Y0}.
FT   REGION      138    157       Disordered. {ECO:0000256|MobiDB-lite:
FT                                E7F7Y0}.
FT   REGION      299    331       Disordered. {ECO:0000256|MobiDB-lite:
FT                                E7F7Y0}.
FT   REGION     1479   1531       Disordered. {ECO:0000256|MobiDB-lite:
FT                                E7F7Y0}.
FT   COMPBIAS    299    329       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                E7F7Y0}.
FT   COMPBIAS   1479   1526       Polar. {ECO:0000256|MobiDB-lite:E7F7Y0}.
SQ   SEQUENCE   1612 AA;  182360 MW;  A145AB726AC68E80 CRC64;
     MEPNQEITMW LTELHLPQYA TSFTLAGYHF LKDLRNLNEE KLLEMDNIPT GHRRRILSSL
     ETLMMEVEGS SVKVPVKRKP IPRPRQVLSK DKQKEASTYQ HAQAGNVQMT RQTLPARTTA
     YSGTMNVGSQ TLPRIKCHAA SSGSSSTSDN GSSESLENFT EDHVTNKSGG LPADGAALGF
     QGEMVENEIY EECLFATVPS EPRSTRSFKL RHRPVPEIPE HPFIPSYDRN VAGNNNTDHL
     TRSEGLILPP SHQKASLERT LSPISPYGEL FLFNSAENVL DLSKDEMSNQ VKETLEQQKL
     RHKQTQAKEK VHYNNKQDLS KQHIDDDKNV DENDYDDYST VQASSFCQQI TNEHPTPPTL
     LSSTGPSAVS AQSQADVNVI YSLAHDDQPG LLKPSVPPRT DLSISPYACF YGICKTATKA
     GWLDKLSPQG NCVFQRRWVK LEGGNLTYYN SEKEMYSKGL IPLSAVKQIR ALGENKFEVV
     TTLRTFVFRA EKEGDRQDWL EVLQAAVSSQ SSVSHQPRKN NTNKSGYVEL RGLKGRVYLS
     LMGTCFRLCK TDQDFNAGLA IAVVDLTAAC VKQFERKGLE ITTPFKSFCF TVESEHERDE
     WIEAVQESIV ETLCNYEVLE KVWFNKSNRK CADCQAPEPE WASINLCVVI CKNCAGQHRF
     LGPGISKVRS MKLDSSIWTN ELIELFLEVG NKNSNSLWVA NLPPEDELCK QSSTEQRASF
     IRRKYKKRKY KKVLNGLNTQ EELNKALCAA VVLPDVLQTM ALVFSGADVM CATGDPELST
     PYLLAQKAGQ RLQMEFLYHN KLSDFPKLEA ICDSSFAADA PSFMDGFLYC SANAGKATLD
     RKGKPDMVRR WCTLEGGFLS YYDNEKIATP IGRVDIGDVV SLAINNNQTI TETGPVFTFE
     LYLRSQRVLV FGVETSDAHQ DWTNAIAKSF VPPRADALLR QDSELIGRLY YKEGHDLYHW
     RIGWFTLVGS ELYFCSGDED EEEGVLQLKR LQELTVSTHI EGDENIQVLL MVESGRTLYI
     HCITKQDFAL WHSAIQLAAG TDGMALSNQQ MNKNDVPIIV DSCIAFVTQY GLCYEGIYQK
     KGDPGRVAHL IQEFTKDARV VKLRVQEQRL EDVTDTLKSF LSHSEDALLA KELYPFWISA
     LDEQDEKVRV QKYSSYIQSL PKVNRSTLGA LLQHLYRIQR CSHINQMSSQ RLACVFSSCL
     FQTEGHTAQE TQVVEDLINN YIQLFSVNDE QVRQMEKENS FITRWKDTTF SPAGDLIFEA
     YLEKKEPEKC CLIKISPNMR SDELAVSTLE MKGMEVKAQD LWTTFEVIEN GEMERPLHYK
     EKVLEQVLEW RSLEDPSSAF LLIKKYSGCK MTDSNSDKLK DFIKGEHLKF KDGSSKLLLG
     NKFQDRYLVL QDKKLLLYKD IKSTKPEREA PLKAVKCYFG LRRKLKPTSS WGFTVYTEKQ
     QWYFCCKGND SQQDWVTSII RMKHGSDLWP RDLKQSTSLP YNLSRRRTST QSTTQSSNKN
     QREVKGKSVL TTSTEDSNTQ NQMAADEGIR PDSLHKLASA EGTPGVSRLE MVIDDTLQSQ
     RRASLQQDTA TLTQISQRKA AIPGRGVQLP QNLINELSTV LNKTGRSQKE AD
//
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