ID E7F8V4_DANRE Unreviewed; 285 AA.
AC E7F8V4; A0A8M3AVK5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 9 isoform X1 {ECO:0000313|RefSeq:XP_009295266.1};
DE SubName: Full=Tumor necrosis factor receptor superfamily, member 9a {ECO:0000313|Ensembl:ENSDARP00000124913};
GN Name=tnfrsf9a {ECO:0000313|Ensembl:ENSDARP00000124913,
GN ECO:0000313|RefSeq:XP_009295266.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060421-8213};
GN Synonyms=zgc:136557 {ECO:0000313|RefSeq:XP_009295266.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000124913};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000124913}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124913};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000124913, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124913};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009295266.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009295266.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; BX663608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009295266.1; XM_009296991.3.
DR STRING; 7955.ENSDARP00000124913; -.
DR PaxDb; 7955-ENSDARP00000110483; -.
DR Ensembl; ENSDART00000150153; ENSDARP00000124913; ENSDARG00000060498.
DR Ensembl; ENSDART00000150153.3; ENSDARP00000124913.1; ENSDARG00000060498.8.
DR GeneID; 678622; -.
DR AGR; ZFIN:ZDB-GENE-060421-8213; -.
DR CTD; 678622; -.
DR ZFIN; ZDB-GENE-060421-8213; tnfrsf9a.
DR eggNOG; ENOG502S017; Eukaryota.
DR HOGENOM; CLU_083349_0_0_1; -.
DR OMA; YLFKQPF; -.
DR OrthoDB; 5471029at2759; -.
DR PhylomeDB; E7F8V4; -.
DR TreeFam; TF336151; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000060498; Expressed in spleen and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR CDD; cd13424; TNFRSF9_teleost; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034057; TNFRSF9_N_teleost.
DR PANTHER; PTHR47139; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9; 1.
DR PANTHER; PTHR47139:SF4; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9 ISOFORM X1-RELATED; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_009295266.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..285
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157052"
FT TRANSMEM 203..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 64..102
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 64..102
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 261..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 81..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 84..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 285 AA; 30794 MW; FF510DEE390E7E66 CRC64;
MLAGFPGLYS LLIFSLVLNL TVGVDVGCQN WTPSGKNYVC CTSCKPGNRL VKRCGYDPAE
LCKPCEPGTY ITGTDFSCDI CTQCIGIQFV AKNCTSSSDT VCGCKPGFRC GDAKCSHCVT
ECKKGEEPKG RVCGQCPEGK FSDKIHSTCK EWTKSSCPDG YKLKKGNLTS DSTCIPPPSS
SVRTVTEQET LPVISKEKDE MNWLPVLIAA MIAGLALLCI ILSVVAYVKA QNKTKKKAKT
EQGNSDDSTI MVVEQEHCSF HHPEQEQGGS SQSINTENSE SKLIV
//
